p53、nm23基因在喉鳞癌中的异常表达

The abnormal expression of p53 and nm23 genesin larynx sguamous carcinoma

目的：探讨ｐ５３ 、ｎｍ ２３ 基因在喉鳞癌中的异常表达与预后的关系。方法：应用免疫组织化学方法对３９例喉鳞癌石蜡标本进行ｐ５３ 蛋白、ｎｍ ２３ 蛋白检测。结果：１８ 例（４６－１ ％ ） 喉癌呈ｐ５３ 过度表达；２９ 例（７４－４％ ） 喉癌呈ｎ ｍ２３ 阳性表达。ｐ５３ 蛋白的阳性过度表达与ｎ ｍ２３ 阳性表达与喉癌的临床分期、颈淋巴结转移及５ 年生存率密切相关。结论：ｐ５３ 蛋白、ｎｍ ２３ 蛋白表达可作为临床预测喉癌颈淋巴结转移及预后的重要参考指标。

Objectives:To observe the correlation between the expression of p53, nm23 protein and the clinical staging and prognosis of human laryngeal squamous cell carcinoma (SCC). Methods:p53 and nm23 protein expression were detected by immunohistochemical technique with formalin fixed paraffin embedded specimens from 39 patients with SCC of larynx. Results:The positive rates of p53 and nm23 were 46 1%(18/39) and 74 4%(29/39) respectively. Regardless of age, sex, and pathologic types, the positive rates of p53 and nm23 were related to clinical staging, neck lymph node metastasis and five year survival rate of SCC of larynx. Conclusion:The detection of p53 and nm23 may be considered as indicators for neck lymph node metastasis and prognosis of human laryngeal squamous cell carcinoma.