摘要
原癌基因bc1 2属抗凋亡基因 ,它不促进细胞增殖 ,但能延长细胞的生命期限。Bc1 2在许多细胞增殖性疾病的发生中起着非常重要的作用。通过影响组织细胞内bc1 2基因的表达 ,为临床上一些退行性疾病及细胞增殖性疾病的治疗提供新的思路。Bc1 2在眼科领域的研究主要集中于遗传性和环境因素所致的视网膜变性。Bc1 2的过表达可以阻止实验性缺血、视神经挫伤、光诱导损伤以及一些视蛋白和cGMP磷酸二酯酶缺陷所致的视网膜光感受器凋亡 。
Protooncogene bc1 2 belongs to antiapoptosis gene family,it does not promote cell proliferation but it is able to prolong the life span of cells.Bc1 2 protein has been shown to contribute to the genesis of many cell proliferative diseases.It may provide an approach for treating degenerative diseases and cell proliferative diseases by affecting the expression of Bc1 2 protein.Research on bc1 2 in ophthalmology mainly focuses on inherited and environmentally induced retinal degenerations.Over expression of bc1 2 reduces apoptotic photoreceptor cell death by experimental ischemia,optic tract lesion,constant light and by a defective opsin or cGMP phosphodiesterase,but doesn’t prevent photoreceptor cells from apoptosis by certain genetic mutations.
出处
《眼科研究》
CSCD
1999年第5期409-410,共2页
Chinese Ophthalmic Research
