代谢综合征相关因素对2年糖尿病转归的影响

Influence of the Related Factors of Metabolic Syndrome on the Clinical Outcome of Diabetes within 2 Years among the Group of Teachers

目的探讨代谢综合征(MS)相关因素对非糖尿病教师人群2年后糖尿病(DM)转归的影响。方法对688名非糖尿病教师测量血糖、血脂、血压、身高、体重、腰围等MS相关因素,观察2年后DM的转归情况并进行分析。结果 2年后仍为正常糖调节者(NGR)和糖调节受损(IGR)人群,原BMI、WC、SBP、DBP、FPG、2hPG、TG、TC、HDL-C均低于2年后转为DM人群,差异有统计学意义(P<0.05);非糖尿病患者2年后的DM转化率为5.4%,其中MS组的糖尿病转化率高于非代谢综合征(NMS)组,糖耐量减低(IGT)组、空腹血糖受损(IFG)组的糖尿病转化率高于NGR组,差异有统计学意义(P<0.01)。结论 MS相关因素明显增加患糖尿病风险,体重和血糖是影响MS转归的重要因素。

Objective To research on the influence of the related factors of metabolic syndrome（MS） on the outcome of type 2 diabetes in 2 years among the group of non-diabetic teachers.Method A two-year follow-up study had been conducted among 688 non-diabetic teachers of Inner Mongolia Agricultural University since the 2006 physical check-up,testing and measuring blood glucose,blood lipid,blood pressure（BP）,body height,weight and waist.The outcomes were compared and analyzed.Results The results of BMI、WC、 SBP、DBP、FPG、2hPG、TG、TC and HDL-C2 years ago of the group of people whose glucose regulation has remained normal or become impaired 2 yeas later were much lower than those of the group who had become diabetic 2 years later.The difference had a statistical significance（P 0.05）;The rate of non-diabetic subjects becoming diabetic 2 years later was 5.4%,among them the rate of the MS group was higher than that of the NMS group and the rate of IGT and IFG group was higher than that of the NGR group,this difference also had a statistical significance（P〈0.01）.Conclusion The related factors of metabolic syndrome increases the risk of diabetes,among them,body weight and blood glucose level are the most important factors which can affect the clinical outcomes of metabolic syndrome.