血浆内脏脂肪素和脂肪细胞型脂肪酸结合蛋白与冠心病的关系

Correlation of Coronary Artery Disease with Plasma Levels of Serum Visfatin and Adipocyte Fatty Acid Binding Proteins

目的探讨血浆内脏脂肪素和脂肪细胞型脂肪酸结合蛋白浓度与冠心病的关系。方法经冠状动脉造影选取120例患者,用病变血管支数表示冠状动脉病变程度,酶联免疫吸附法测定患者血浆内脏脂肪素和脂肪细胞型脂肪酸结合蛋白浓度。结果血浆内脏脂肪素和脂肪细胞型脂肪酸结合蛋白浓度在冠心病组高于非冠心病组(P<0.05),在冠心病组双支病变高于单支病变(P<0.05),三支病变明显高于双支病变和单支病变(P<0.05)。结论血浆内脏脂肪素和脂肪细胞型脂肪酸结合蛋白可能成为预测人类冠心病及冠状动脉病变程度的有用指标。

Objective To study the correlation of coronary artery disease with the levels of serum visfatin and adipocyte fatty acid binding proteins. Methods The study cohort included 120 subjects who underwent coronary angiography. Severity of coronary artery lesions was evaluated by the number of diseased arteries. Serum visfatin and adipocyte fatty acid binding proteins levels were determined by ELISA. Results The levels of serum visfatin and adipoeyte fatty acid binding proteins in coronary artery disease group were higher than control group（ P 〈 0.05 ）, and two-vessel disease were higher than single-vessel disease （ P 〈 0.05 ）, triple vessel disease were significantly higher than twovessel disease and single-vessel disease （ P 〈 0.05 ） . Conclusion Serum visfatin and adipoeyte fatty acid binding proteins levels could reflect the extent of coronary artery atherosclerosis.