同型半胱氨酸与急性脑梗死相关性及药物干预研究

Studies on Correlation between Homocysteine and Acute Cerebral Infarction and the Effect of Medicine Intervention

目的探讨同型半胱氨酸(Hcy)与急性脑梗死(ACI)的相关性及药物干预的效果。方法选取确诊的61例急性脑梗死患者和35例健康对照者;分析急性脑梗死时同型半胱氨酸对患者发病及病情的影响,寻找简便可行的预防用药。结果 ACI组中Hcy水平较健康对照组高(P<0.05);而在ACI患者中:SSS评分与Hcy水平呈正相关(r=0.436,P=0.031),NIHSS评分与Hcy水平呈正相关(r=0.412,P=0.028);治疗后干预治疗组的Hcy下降程度也高于非干预治疗组(P<0.05)。结论 Hcy与ACI的发生、病情以及药物干预的关系密切,可作为病情判断及转归的指标,也可作为高危人群早期预防干预的参考指标。

Objective To explore the correlation between homocysteiue （Hcy ） and acute cerebral infarction （ ACI ） , and the effect of medicine intervention. Methods Selected 61 cases with ACI and 35 healthy cases as control group. The effect of Hey on ACI patients＇ eonditions was analyzed to find a convenient preventive medication proposal. Results Hey level of ACI group was higher than that of control group（ P 〈 0.05 ）. SSS score and NIHSS score had positive relations with Hey level（ SSS r = 0.436, P = 0.031; NIHSS r = 0.412, P = 0.028 ） respectively. Decreased level of Hey in intervention group was higher than that of control group （ P 〈 0.05 ） . Conclusion Hey is closely correlated with the occurrence of ACI, pathogenetic condition and the effect of medicine intervention. Thus, Hey could judge the pathogenetic condition anti prognosis of ACI patients, also could be used as the referred indicator of early prevention intervention for high risk group.