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Barrett食管发展到腺癌的细胞和分子机制进展 被引量：4

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摘要 Barrett食管（Barrettesophagus，BE）是胃食管反流病（GERD）最严重的一个类型，它是一种食管腺癌和胃食管腺癌患者的癌前病变。一项内镜筛查研究显示，BE患病率为5．6％。早期研究指出，Barrett肠上皮化生患者比一般人群发生食管腺癌的危险性增加30．125倍，有BE患者食管腺癌发病危险是无BE患者的30～40倍。
作者 池肇春
机构地区 中国海洋大学附属医院青岛市市立医院消化内科
出处 《中国医师进修杂志》 2011年第13期1-3,6,共4页 Chinese Journal of Postgraduates of Medicine
关键词 BARRETT食管 食管腺癌 分子机制 细胞 胃食管反流病 肠上皮化生 癌患者 癌前病变
分类号 R735 [医药卫生—肿瘤]
  • 相关文献

参考文献14

  • 1Morrow DJ,Avissar NE,Toia L,et al.Pathogenesis of Barrett's esophagus:bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cells.Sugery,2009,146(4):714-721.
  • 2Burnat G,Majka J,Konturek PC.Bile acids are multifunctional modulators of the Barrett's carcinogenesis.J Physiol Pharmacol,2010,61(2):185-192.
  • 3Hong J,Behar J,Wands J,et al.Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma.Gut,2010,59(2):170-180.
  • 4MoKrowiecka A,Wierzchniewska-Lawska A,Smolarz B,et al.Polymorphism/loss of heterozygosity of APC gene in GERD-Barrett's metaplasia-dysplasia-adenocarcinoma sequence.Pol Merkur Lekareki,2009,26(155):385-389.
  • 5Nguyen KO.Blain SW,Cress F,et al.Inflammatory mediators of esophagi tis alter p27 Kip1 expression in esophageal epithelial cells.J Pediatr Gastroenterol Nutr,2010,51 (5):556-562.
  • 6Hong J,Resnick M,Behar J,et al.Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S.Am J Physiol Gastrointest Liver Physiol,2010,299(3):G697-706.
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  • 8Rossi E,Villanacci V,Bassotti G,et al.TOPO Ⅱ alpha and HER-2/neu overexpression/amplification in Barrett's oesophagus,dysplasia and adenocarcinoma.Histopathology,2010,57 (1):81-89.
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同被引文献42

  • 1戈之铮,陆秋云,薛寒冰,李伟光,戴军,李晓波,胡运彪.内镜窄带成像技术在诊断Barrett食管中的作用研究[J].中华消化内镜杂志,2007,24(1):14-18. 被引量：36
  • 2Slehria S, Sharma P. Barrett esophagus. Curr Opin Gastroenterol, 2003, 19(4) : 387-393.
  • 3Guillen PG. How to make a Barrett esophagus: pathophysiology of columnar metaplasia of the esophagus. Dig Dis Sci, 2005, 50(3 ) : 415-424.
  • 4The Paris endoscopic classification of superficial neoplastic lesions: esophagus, stomach, and colon: November 30 to December 1, 2002. Gastrointest Endosc, 2003, 58(6 Suppl) :S3-43.
  • 5Curvers W, Baak L, Kiesslich R, et al. Chromoendoseopy and narrow-band imaging compared with high-resolution magnification endoscopy in Barrett's esophagus. Gastroenterology, 2008, 134 (3) : 670-679.
  • 6Sharma P, Wani S, Bansal A, et al. A feasibility trial of narrow hand imaging endoscopy in patients with gastroesophageal reflux disease. Gastroenterology, 2007, 133(2) :454-464.
  • 7Kara MA, Peters FP, Fockens P,et al. Endoscopic video- autofiuorescence imaging followed by narrow band imaging for detecting early neoplasia in Barrett's esophagus. Gastrointest Endosc, 2006, 64(2):176-185.
  • 8Sharma P, Bansal A,Mathur S, et al. The utility of a novel narrow band imaging endoscopy system in patients with Barrett's esophagus. Gastrointest Endosc, 2006, 64(2 ) : 167-175.
  • 9Kara MA, Bergman JJ. Autofluorescence imaging and narrow-band imaging for the detection of early neoplasia in patients with Barrett's esophagus. Endoscopy, 2006, 38(6):627-631.
  • 10Wex T, M nkemtlller K, Kuester D, et al. Gastroesophageal reflux disease does not lead to changes in the secretory leukocyte protease inhibitor expression in esophageal mucosa. Eur J Gastroenterol Hepatol,2009,21 (2) : 150-158.

引证文献4

二级引证文献5

中国医师进修杂志
2011年 第13期

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