米非司酮配伍米索前列醇用于终止12～16周妊娠随机对照研究

A Comparative Study of mifepristone and misoprostol on termination of 12-16 gestational weeks

目的：探讨米非司酮配伍米索前列醇用于12-16周妊娠的效果及安全性。方法：采用随机对照研究的方法对295例孕妇（孕龄12-16周）进行观察研究，试验组145例，采用米非司酮配伍米索前列醇终止妊娠；对照组150例，采用依沙吖啶经阴道官腔内羊膜腔外插管注药终止妊娠。结果：试验组终止妊娠成功率为96．6％，明显高于对照组80．7％（P〈0．05）；试验组诱导宫缩时间及胎儿胎盘娩出时间均明显短于对照组，差异有统计学意义（P〈0．05）。两组出血量比较，差异无统计学意义（P〉0．05）。结论：米非司酮配伍米索前列醇用于终止12—16周妊娠成功率高、时间短、安全简便，值得推广。

Objective：To study the clinical effect and security of Mifepristone and Misoprostol applied on the termination of 12 - 16 gestational weeks. Methods： 295 healthy pregnancy women with 12 - 16 gestational weeks were randomly divided into two groups including observation group （145 cases）with mifepristone and mlsopmstol and control group （ 150 cases） with transvaginal. Result：The success rates of abortion in observation group and control group were 96.6 % and 80.7 %, respectively（ P 〈 0.05 ）. There was a significant difference between the two groups in the time of Contractions time and induced abortion （ P 〈 0.05 ）. There were no significant differences between groups in uterine bleeding（ P 〉 0.05 ）. Conclusion： The application of mifepristone and misoprostol on terimination of 12 - 16 gestatlonal weeks demanstrates advantages in high success rate, short time, simplicity, safety,it can be promotion.