超声造影对诊断肝细胞性肝癌的应用探讨

A clinical study of contrast-enhanced ultrasonography on diagnosis of hepatocellular carcinoma

目的:应用超声造影技术观察其对肝细胞性肝癌的诊断价值。方法:观察组肝细胞性肝癌组患者30例34个结节,对照组肝内胆管细胞癌组患者8例12个结节。观察注射造影剂Sono Vne后两组肿瘤结节的血流灌注特征,并用ImageLab软件分析造影增强期及消退期各参数。结果:两组造影特征均为"快进快出",两组间的始增时间、峰值时间、增强时间及下降斜率等参数差异均无显著性(P>0.05)。但到达峰值时间时,两组肿瘤结节血流灌注模式的差异具有显著性(P<0.05),肝细胞性肝癌组主要表现为整体型(22/34)或部分型(10/34),肝内胆管细胞癌组主要为周边型(10/12)。结论:超声造影技术对肝细胞性肝癌具有良好的诊断价值。

Objective： To analyze the value of hepatocellular carcinoma （ HCC ） using contrast - enhanced u 1 trasenography. Methods： The study involved 3 8 patients with pathological evidence through surgery or needle biopsy, including 30 HCCs with 34 nodules, and 8 ICCs with 12 nodules. The blood perfusion characteristics of two groups were observed after the injection of contrast ultrasound agent（ Sono Vue）. And parameters of the time - intensity curve during contrast enhancement period（ enhancement beginning time, peak intensity time, and enhancement time）and falling slope during contrast diminishm ent period were analyzed by ImageLab software（Toshiba）. Results：All of nodules of two groups presented with early artery enhancement and immediate wash -out. The shapes of the time - intensity curves of the two groups were similar and there were no significance （ P 〉 0.05 ） in differentiating from parameters of the two groups. Three enhancement patterns were observed at time to peak intensity： holistic enhancement pattern, partial enhancement pattern, and peripheral enhancement pattern. There were significance （ P 〈 0.05 ） in differentiating from enhancement patterns of the two groups. The holistic （22/34） and partial（10/34） enhancement patterns were mostly shown in HCC, the peripheral （10/12） enhancement pattern was mostly shown in ICC. Conclusions：Contrast - enhanced ul trasenography is a promising method to provide useful information for the diagnosis of HCC.