初诊与非初诊2型糖尿病患者短期胰岛素泵(CSII)强化治疗应用的胰岛素剂量比较

Comparison of continuous subcutaneous insulin infusion(CSII) curative effect in newly versus previously diagnosed type 2 diabetes

目的:比较初诊与非初诊2型糖尿病患者短期胰岛素泵(CSII)强化治疗应用的胰岛素效果。方法:对本院T2DM患者349例泵用胰岛素行CSII治疗,比较其达标天数、达标时用量、开始减量时间和撤泵时用量,并分析血糖达标时间和达标时胰岛素用量的相关因素。结果:初诊组达标时间(4.79±2.59)天,非初诊组(5.77±2.58)天,与非初诊组相比,达标时间与减量时间更早、撤泵时的日总量也较低,基础用量均占全天用量的61%左右。血糖达标时间主要非初诊、FBG、HbA1c、2hBG正相关,而达标时胰岛素用量与非初诊、年龄、BMI、WHR、HbA1c呈正相关。结论:CSII短期强化治疗初诊与非初诊2型糖尿病患者疗效均很显著,初诊患者疗效更好。

Objective：To compare the curative effect of continuous Subcutaneous insulin infusion （CSU） in newly and previously diagnosed type 2 diabetic patients. Methods：349 patients were treated by CSII and their blood glucose（BG） levels,days needed for good control, insulin dosage and correlative factors and the frequency of hypoglycemia were observed. Results：Optimal glycemic control was achieved within 4.79 ±2, 59d （newly diagnosed） and 5, 77 ± 2.58d （previously diagnosed） respectively（ P 〈 0.05 ）. Basal/daily insulin dosage ratio were both about 61% in two groups. The dosage of insulin was reduced more early and quickly in the newly diagnosed group than in non -newly diagnosed group. Optimal glyeemic control was related to newly diagnosed、FBG、HbA1c.2hBG and the insulin dosage was related to the newly diagnosed.age.BMI、WHR and HbA1c. Conclusion：CSII is effective when applied in both the newly and nonnewly diagnosed type 2 diabetic patients and curative effect was better in newly diagnosed.