吸入丙酸氟替卡松加孟鲁司特预防毛细支气管炎后反复喘息疗效分析

Inhaled fluticasone and Montelukast prevent recurrent wheezing after bronchiolitis efficacy

目的对痊愈出院的毛细支气管炎患儿进行吸入丙酸氟替卡松加孟鲁司特治疗,观察该方法预防病后喘息再发作的疗效。方法前瞻性研究,将100例痊愈出院的毛细支气管炎患儿随机分成两组,治疗组和对照组,跟踪随访1年,观察并统计两组在观察期内喘息再发作的病例、发作次数及持续的时间。结果治疗组出现再发喘息病例数明显少于对照组,差异有统计学意义(P<0.05),且用药期间未见不良反应。结论吸入丙酸氟替卡松加孟鲁司特预防毛细支管炎后反复喘息疗效确切、不良反应小,可作为预防毛细支管炎后反复喘息的干预措施,值得临床推广。

Objective To explore the therapeutic efficacy of inhalation of fluticasone with montelukast in the preventing infant recurrent wheezing after acute bronchiolitis.Methods One hundred cases recovering from acute bronchiolitis were divided randomly into two groups.The treatment group（n=50）treated with inhalation of fluticasone with montelukast,the control group（n=50）treated with nothing.Statistics breath and then attack the two groups appear in future the number of cases.Results Treatment group had recurrent wheezing number of cases is significantly less than the control group,there was a significant difference,no side effects and medication.Conclusions Inhalation of fluticason combined with montelukast is really efficaci ous in the preventing infant recurrent wheezing after acute bronchiolitis,with less side-effect,and is worth clinical application.