3种不同肠道准备方法清洁结肠效果的比较

Compare the Efficacy and Safety of Three Methods of Bowel Preparation before Colonoscopy

目的:探讨一种安全、有效地肠道准备方法,以增加结肠镜检查的成功率与受检者的依从性,减少并发症。方法:将接受结肠镜检查的200例患者随机分为A组(68例)、B组(73例)和C组(59例)。A组口服聚乙二醇电解质散剂,B组口服硫酸镁,C组口服甘露醇。如遇习惯性便秘者,均提前3d给予缓泻剂,使每天有稀糊状或软便。观察3种不同方法的肠道清洁度、镜检成功率以及不良反应。结果:3组的肠道清洁度满意率均较高,A组为88.24%,B组为91.78%,C组为86.44%。3组均无严重不良反应发生。不良反应发生率,A组为11.76%,B组为24.66%,C组为32.20%。A组,B组和C组比较有显著差异(P<0.05)。结论:聚乙二醇电解质散剂应用于肠道准备效果满意,不良反应小,值得临床广泛应用。

Objective： To explore an effective and safe method of bowel preparation before colonoscopy and to improve patient tolerance,effectiveness,and acceptability for colonoscopy cleansing.Methods： A total of 200 patients undergoing colonoscopy for routine indications were randomized to 3 groups,Group A was given sulfate-free polyethylene glycol electrolyte solution（SF-PEG）.Group B was given MgSO4,while Group C was given Manicol liquid.The day before scheduled colonoscopy,study subjects were allowed a normal breakfast and clear liquids for lunch and dinner.Patient tolerance and various hematological and biochemical parameters were assessed.Results： Physician assessment of colon cleansing showed no differences between those patients.Bowel cleaning rate were 88.24%,91.78%,86.44% in Group A,Group B and Group C,respectively.There no statistical significant difference among the 3 groups（P〈0.05）.Group A had less fullness,nausea,vomiting,and overall discomfort compared with both Group B（P〈0.05） and Group C（P〈0.01）.There were no clinically significant changes in hematology or blood chemistry associated with either preparation.Conclusions：Sulfate-free polyethylene glycol electrolyte solution is safe and effective.Clinical symptoms from the reduced volume preparation are significantly reduced compared with Manicol liquid and MgSO4.