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调节性T细胞的功能与Foxp3基因及组蛋白甲基化状态的研究进展 被引量：1

Advances in the Relationship between the Function of Regulatory T Cells and Methylation of Gene Foxp3 and Histones
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摘要 自从Sakaguchi首次证实调节性T细胞（regu-latory Tcells,Treg）的存在及功能至今,其一直是免疫领域内的研究热点。Treg能抑制免疫系统对自身和某些外来抗原的应答,在维持机体免疫耐受和免疫稳态方面具有非常重要的作用。现已证实,除了CD4^＋Treg外,部分CD8^＋T细胞、
作者 杨橙 赵天 戎瑞明 朱同玉
机构地区 复旦大学附属中山医院泌尿外科 上海市器官移植重点实验室
出处 《中国临床医学》 2011年第2期262-265,共4页 Chinese Journal of Clinical Medicine
基金 上海市科委(编号:09DZ2260300) 国家"十一五"课题(编号:2008BAI60B04)
关键词 调节性T细胞 FOXP3基因 甲基化状态 组蛋白 CD8^+T细胞 免疫系统 免疫稳态 免疫耐受
分类号 R392.4 [医药卫生—免疫学]
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参考文献34

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同被引文献28

  • 1Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4~D25~ regulatory T cells[J]. Nat Immunol, 2003, 4(4): 330-336.
  • 2Zhou X, Bailey Bucktrout S, Jeker LT, et M. Plasticity of CD4(+) FoxP3(+) T cells[J]. Curr Opin Immunol, 2009, 21(3): 281-285.
  • 3Rubtsov YP, Niec RE, Josefowicz S, et al. Stability of the regulatory T cell lineage in vivo[J]. Science, 2010, 329(5999): 1667-1671.
  • 4Sakaguchi S, Vignali DA, Rudensky AY, et al. The plasticity and stability of regulatory T cells [J]. Nat Rev Immunol, 2013, 13(6): 461-467.
  • 5Abbas AK, Benoist C, Bluestone JA, et al. Regulatory T cells: recommendations to simplify the nomenclature[J]. Nat Immunol, 2013, 14(4): 307-308.
  • 6Goldstein JD, Perol L, Zaragoza B, et al. Role of eytokines in thymus- versus peripherally derived-regulatory T cell differentiation and function [j]. Front Immunol, 2013, 4: 155.
  • 7Kitagawa Y, Ohkura N, Sakaguehi S. Molecular determinants of regulatory T cell development: the essentialroles of epigenetic change[J]. Front hnnmnol, 2013, 4: 106.
  • 8Miyara M, Yoshioka Y, Kitoh A, et al. Functional delineation and differentiation dynamic, s of human CD4+ T cells expressing the FoxP3 transcription factor[J]. Immunity, 2009, 30(6): 899-911.
  • 9Hou J, Sun Y, Hao Y, et al. Imbalance between subpopulations of regulatory T cells in COPD [J]. Thorax, 2013, 68(12): 1131-1139.
  • 10Zhou H, Zhao H, Hao Y, et al. Excessive conversion and impaired thymic output contribute to disturbed regulatory T-cell homeostasis in AIDS patients with low CD4 cell counts[J]. AIDS, 2013, 27(7): 1059-1069.

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二级引证文献3

中国临床医学
2011年 第2期

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