环丙沙星浓度微生物测定法的建立

Establishment of Microbioassay for the Efficacy of Ciprofloxacin

第三代氟喹诺酮类药物环丙沙星(Ciprofloxacin cIP)抗菌活性居该类药物之首,环丙基的引入增加了它在各种组织中的穿透性和生物利用度,而且其部分代谢产物仍具有抗菌活性。CIP的疗效与感染部位组织中的药物浓度直接相关,为保证感染部位的有效浓度,确保临床疗效,应将药物的组织渗透性、局部药物浓度及抗菌活性综合考察。

We have established a simple and accurate assay for the antibacterial efficacy of ciprofloxacin (CIP), using the most appropriate concentration of CIP and agar, pH condition, and suitable temperature. This method may be applied to the assay of clinical samples such as plasma, tissue, and body fluid, etc.