绞股蓝总皂甙对Lewis肺癌荷瘤小鼠肿瘤生长及免疫功能的影响

Effects of gypenosides on neoplasm growth and immunity function of Lewis lung neoplasm grafted mice

目的 :观察绞股蓝总皂甙 (gypenosides,GPs)对Lewis肺癌荷瘤小鼠肿瘤生长、脾淋巴细胞数及NK活性的影响。方法 :整体动物的抑瘤试验、脾淋巴细胞计数及NK活性测定。结果 :GPs对荷瘤小鼠Lewis肺癌细胞具有明显的抑制作用 ,在剂量 1 0、2 0、4 0mg/kg腹腔注射 (ip)给药条件下 ,其抑瘤率分别为 (3 0 7± 1 2 ) % ,(51 5± 2 5) %和 (50 3± 1 5) % (P <0 0 1 )。同时 ,GPsip给药后荷瘤小鼠脾淋巴细胞总数明显增加 ,外周血淋巴细胞NK活性明显升高 ,脾淋巴细胞NK活性也明显升高。结论 :GPs的抗肿瘤作用与其对荷瘤小鼠免疫功能的增强作用密切相关。

OBJECTIVE:To study the effects of Gypenosides (GPs) on neoplasm growth, total number of splenic cells and NK cell activity. METHODS:Antitumor experiment in mice was made and the total number of splenic cells and NK cell activity were determined. RESULTS:GPs could significantly inhibit the growth of Lewis lung cancer in mice. The inhibiting rates of tumor were (30.7±1 2)%,(51 5±2 5)% and (50.3±1.5)% ( P <0 01) after ip GPs 10,20 and 40mg/kg,respectively. The total number of splenic cells and the NK cell activity of both PBL and splenic cells were elevated. CONCLUSION:The antitumor effect of GPs is related to the elevated immunological function of tumor grafted mice.