带状疱疹的早期综合治疗

EARLY COMPREHENSIVE TREATMENT ON HERPES ZOSTER

目的:通过对带状疱疹的早期诊断及早期综合治疗,观察其对急性期疼痛缓解及后遗痛预防的疗效。方法:36例带状疱疹急性期病例随机分成治疗组及对照组,治疗组采用抗病毒药物、曲马多、加巴喷丁、局部神经阻滞及超激光照射治疗。对照组采用抗病毒药物、布洛芬缓释胶囊、局部神经阻滞及超激光照射治疗。采用VAS评分及睡眠影响指数(SIS)对疼痛程度及患者生活质量进行评价。结果:治疗前,治疗组VAS及SIS平均为6.81±1.76及6.62±1.86,对照组VAS及SIS平均为6.57±1.45及6.43±1.75;治疗五周后,治疗组VAS及SIS平均为1.38±1.47及1.02±1.71,对照组VAS及SIS平均为2.27±0.92及2.00±0.65。治疗组后遗痛的发生率为4.8%,对照组为13.3%。结论:带状疱疹的早期诊断及综合治疗不仅可以减轻急性症状,还可减少带状疱疹后神经痛(PHN)的发生率。

Objective： To evaluate the effects of the early diagnosis and comprehensive treatment on the pain score of acute phase of zoster and the incidence rate of postherpetic neuralgia. Methods ：36 patients with Herpes Zoster were randomly divided into treatment group and control group. The treatment group was given comprehensive treatment with antiviral drug, tramadol, gabapentin, local nerve block and super laser irradiation, while the control group was only treated with antiviral drug, ibuprofen, local nerve block and super laser irradiation. The effect was evaluated by visual analogue scale （VAS） and sleep interference score（SIS）. Results： VAS and SIS of the treatment group were 6.81 ± 1.76 and 6.62 ± 1.86 respectively before treatment, and the control group were 6.57 ±1.45 and 6.43 ± 1.75 respectively. After treatment for 5 weeks, VAS was decreased to 1.38 ± 1.47 and SIS was decrease to 1.02± 1.71 in treatment group, while VAS was decreased to 2.27 ±0.92 and SIS was decrease to 2.00 ± 0.65 in control group. The incidence of postherpetic neuralgia （PHN） in study group was 4.8% and 13.3% in the control group. Conclusion ： The efficacy of early diagnosis and comprehensive treatment on Herpes Zoster not only relieve the acute symptoms, but also reduce the incidence of PriN.