普罗碘铵经血-眼屏障的渗透性研究

Permeability study on prolonium iodide through blood-ocular barrier

目的:测定普罗碘铵经肌肉注射后,不同时间点家兔玻璃体中碘的质量浓度,进而研究此药经血-眼屏障的渗透性。方法:健康成年家兔50只随机分为2组,Ⅰ组为空白对照组,Ⅱ组每只家兔肌肉注射普罗碘铵24mg/kg。各组在用药后1,3,6,12和24h分别取玻璃体,测定其中碘浓度。结果:肌肉注射组玻璃体内碘含量与空白对照组比较具有显著统计学差异(P<0.01)。经肌肉注射后3h,兔玻璃体内碘浓度达峰值,以后逐渐减少,24h后仍高于空白对照组水平。结论:普罗碘铵经肌肉注射能透过血-眼屏障进入眼内,代谢缓慢。

·AIM：To determine iodine concentration of the rabbit vitreous body in the different time after prolonium iodide intramuscular injection,in order to study its permeability through blood-ocular barrier.·METHODS：Fifty adult rabbits were randomly divided into 2 groups.Ⅰgroup was the normal control group;in the Ⅱ group,every rabbit was injected 24mg/kg prolonium iodide with intramuscular injection;After using the drug,every group was determined iodine concentration of vitreous body using Arsenic and Cerium catalysis spectrophotometry in different time.·RESULTS：Iodine content of vitreous body in the intramuscular injection groups was obviously different from that in the normal control group.3 hours after intramuscular injection,iodine concentration in the rabbit vitreous body got to peak value and then began to decline,it was still higher than normal level after 24 hours.·CONCLUSION：Prolonium iodide can enter eye through blood-ocular barrier and metabolize slow through intramuscular injection.·