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帕金森病基因修饰模型的研究进展

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摘要 帕金森病（PD）是一种常见于中老年人的缓慢进展性神经系统退变性疾病,典型的行为学及病理学特征包括：进行性运动障碍,如运动迟缓、静止性震颤、僵直、步态不稳等,黑质致密部多巴胺能神经元进行性丢失以及残存神经元内路易小体（Lowy bodies,LB）的形成。目前认为,PD的发生、发展与基因突变、蛋白水解应激、氧化应激、免疫学异常等诸多机制有关,
作者 李岩 徐淼
机构地区 山东大学药学院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2011年第8期1475-1478,共4页 Chinese Journal of Gerontology
关键词 帕金森病 实验模型 基因修饰 发病机制
分类号 Q95-33 [生物学—动物学]
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参考文献31

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二级参考文献10

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中国老年学杂志
2011年 第8期

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