慢性乙型肝炎患者年龄、血脂代谢与HBV-DNA的相关性

Relationship of HBV-DNA to Age and Blood Lipid Metabolism of Patients with Chronic Hepatitis B

目的分析慢性乙型肝炎患者年龄、血脂代谢与HBV-DNA水平之间的相关性。方法对2007年11月～2009年10月在我院感染科住院的788例慢性乙型肝炎HBV-DNA阳性患者(本研究中将HBV-DNA滴度大于1×103拷贝/ml定义为HBV-DNA阳性)的临床资料进行回顾性分析。用Spearman秩相关分析及多重线性回归分析患者年龄及血脂与HBV-DNA的相关性。结果 Spearman秩相关分析显示,在慢性乙型肝炎HBV-DNA阳性患者中,HBV-DNA水平与患者年龄呈负相关,与血脂中甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)及载脂蛋白A-(IApoA-I)呈正相关;多重线性回归分析显示,HBV-DNA水平与患者年龄、血脂中ApoA-I存在线性依存关系。结论慢性乙型肝炎HBV-DNA阳性患者的HBV-DNA水平与其年龄呈负相关,与ApoA-I呈正相关。

Objective To analyze the relationship of HBV-DNA to age and blood lipid metabolism of patients with chronic hepatitis B.Methods The clinical data on 788 HBV-DNA-positive（with HBV-DNA titers of more than 1 × 103 copies/ml） patients with chronic hepatitis B,hospitalized in The Second Affiliated Hospital of Chongqing Medical University from November 2007 to October 2009,were analyzed retrospectively,based on which the relationship of HBV-DNA to age and blood lipid metabolism was analyzed by Spearman rank correlation and multiple linear regression.Results The result of Spearman rank correlation showed that HBV-DNA level was negatively related to the age of patients and positively related to the triglyceride（TG）,total cholesterol（TC）,high density lipoprotein（HDL）,Low density Lipoprotein（LDL） and apolipoprotein A-Ⅰ（ApoA-Ⅰ） contents in blood.The result of multiple linear regression showed that HBV-DNA level was linearly dependent to the age and ApoA-Ⅰcontent of the patients.Conclusion The HBV-DNA level of patients with chronic hepatitis B was negatively related to the age and positively related to ApoA-Ⅰ content.