根除幽门螺杆菌后胃黏膜肠上皮化生的变化

Changes of Gastric Intestinal Metaplasia after Helicobacter Pylori Eradication

目的：探讨根除幽门螺杆菌（Hp）慢性感染对胃黏膜肠上皮化生的远期疗效。方法：随访319例肠上皮化生的患者,其中根除组182例,未根除组137例,分析不同程度胃黏膜肠上皮化生在不同手术方式中随时间变化的情况。结果：轻度肠上皮化生在Hp根除后13~36个月和37~70个月与未根除组比较差异有统计学意义（P〈0.05或P〈0.01）。中度肠上皮化生仅在Hp根除后37-70个月与未根除组比较差异有统计学意义（P〈0.05）。重度肠化在随访的6-70个月内差异均无统计学意义（P〉0.05）。结论：轻中度胃黏膜肠上皮化生患者根除幽门螺杆菌慢性感染后可逆转。

Objective： To investigate the chronic long-term effect of gastric intestinal metaplasia after the eradication of helicobacter pylori （Hp）. Methods： The total of 319 cases of intestinal metaplasia, including 182 cases of the eradication group and 137 cases remained Hp positive, were followed up, and which of the changes with the time was analyzed. Results： There was significant difference in the mild intestinal metaplasia in patients of the eradication group after 12~36 months and 36~70 months compared with those of non-eradication group（P 0.05 or P 0.01）. There was significant difference in the moderate intestinal metaplasia 37~70 months after Hp eradication in patients of the eradication group（P 0.05）. The severe intestinal metaplasia did not change within 6~70 months after Hp eradication （P 0.05）. Conclusion： The long-term effect can be received in patients with mild and moderate gastric intestinal metaplasia after eradication of helicobacter pylori.