摘要
采用高效液相色谱法测定大鼠静脉注射芍药苷和灌胃给予白芍煎剂后血浆中芍药苷浓度,静脉注射后的数据经3P87处理,灌胃后的数据以非隔室模型处理.结果表明大鼠静脉注射芍药苷(15mg/kg)后,血药浓度时间曲线符合二室模型,药动学参数为T1/2α=26min,T1/2β=274min.大鼠灌胃白芍煎剂(相当于芍药苷850mg/kg)后,生物利用度为F=312%,Tmax=102min,Cmax=993mg/L.大鼠灌胃白芍煎剂后芍药苷的绝对生物利用度仅为3%,提示芍药苷有可能发生了生物转化.
TheabsolutebioavailabilityofpaeoniflorinafteradministrationoftheDecoetumPaeo niaeinratswasstudied .TheplasmaconcentrationofpaeoniflorinwasdetectedbyHPLC .The plasmaconcentrationofpaeoniflorinafterintravenousadministrationatthedoseof 1 5mg/kg rapidlydecreased .Theterminalhalf lifewas 2 7 4min .Thedrugwasfoundtoconformtoatwo compartmentmodelafterintravenousadministration .WhengivenorallywiththeDecoctumPaeo niaeRad .decoction ,theabsolutebioavaliabilityvalue(F)determinedbytheAUCwas 3 .1 2 % . TheTmax was 1 0 2min ,Cmaxwas 9.93mg/L .Theabsolutebioavailabilityvalueswereverylow , whichsuggestedithadbeenmetabolized .
出处
《沈阳药科大学学报》
CAS
CSCD
1999年第4期250-253,共4页
Journal of Shenyang Pharmaceutical University
