蜕皮甾酮对东莨菪碱致记忆障碍的改善作用

The Improving Effect of Ecdysterone on Scopolamine-lnduced Amnesia

采用一次性被动迥避式反应方法(跳台法、避暗法)、水迷宫法及穿梭箱法研究了蜕皮甾酮对东莨菪碱造成的小鼠记忆障碍的改善作用.结果表明,蜕皮甾酮36、72mg/kg能明显改善东莨菪碱造成的记忆获得障碍,蜕皮甾酮18、36、72mg/kg能拮抗东莨菪碱引起的小鼠空间辨别障碍,蜕皮甾酮25、50mg/kg能改善东莨菪碱引起的大鼠主动迥避反应障碍,提示蜕皮甾酮能改善东莨菪碱造成的记忆损害.

Theimprovingeffectofecdysterone (ECR)onamnesiainducedbyscopolaminewas studiedbyusingthemethodsoftheonetrialpassiveavoidanceresponse(includingthestep down testandstep throughtest) ,watermazetestandshuttle boxtest.TheresultsshowedthatECR 3 , 6,7 2mg/kgpreventedtheacquisitionimpairmentofmemoryinducedbyscopolamineinmice, ECR 1 8,3 6,7.2mg/kgantagonizedthespatialdiscriminatedamageinducedbyscopolaminein miceandECR 2 5,5 0mg/kgalsoprotectedratsagainsttheimparimentofmultipletrainingac tiveavoidanceresponseinducedbyscopolamine.TheseresultsindicatedthatECRhadprotective effectsagainstamnesiainducedbyscopolamine.