断肢再植术后动脉侧支血管建立的实验研究

Experimental study of developing collateral circulation for post-operation of the replanted limbs

目的 研究大鼠断肢再植术后侧支血管形成的规律及其意义。方法 选用成年ＳＤ 大鼠４８ 只，按阻断股动脉的时间不同，随机分成４ ｄ ，１ 、２ 、３ 、４ 、５ 、６ 、８ 周共８ 个组，股动脉切断后对再植肢进行大体、血管造影和组织学检查。结果 ４ ｄ 及１ 周组未见新生侧支血管形成，再植肢坏死；２ 、３ 、４ 、５ 、６ 、８ 周组随着时间的延长，再植肢新生侧支血管逐渐增多增粗并向远侧生长，血循环和成活情况逐渐改善。结论 大鼠断肢再植２ 周后，即使主要动脉阻断。

Objective To study the regularlity and meaning of neovascularization in the replanted limbs of rats. Methods 48 adult SD rats were randamly divided into 4-day,1?,2?,3?,4?,5?,6?,and 8?week groups,according to the periods of time of the interruption of the femoral artery. The naked eye,angiography and histological examination were observed.Results A progresive improvement of neovascularization was observed in the replanted limbs of the rats at 2?,3?,4?,5?,6?,and 8?week groups as the time delay, which were growing stronger and thicker and stretching distally and no neovascularization at 4-day and 1 week group. Conclusions The replanted limbs could survive dependent on neovascularization above two weeks even though their femoral arteria were interrupted.