Fascin在肺癌中的表达及临床探讨

Fascin expression in lung cancer and its clinical significance

目的 探讨Fascin在人肺癌组织中的表达及临床意义.方法 对62例正常肺组织和不同组织学类型及临床分期的肺癌以及92例其它部位恶性肿瘤进行Fascin免疫组化染色,分别计算Fascin的阳性率,统计分析不同病理特征的差异以及肺癌与肺正常组织及其他肿瘤之间的差异.结果 Fascin在肺癌组织中的表达明显高于其在肺正常组织中的表达（P＜0.05）,其表达与肺癌的临床分期、组织分化有关;随着癌分化程度的降低,Fascin的阳性率上升;Fascin的表达与患者的年龄、性别、吸烟史无关（P＞0.05）.Fascin在肺癌组织中与其它部位恶性肿瘤组织中的表达的阳性率比较差异无统计学意义（P＞0.05）.结论 Fascin在恶性肿瘤中的表达上调可能具有普遍性.Fascin在肺组织中的表达提示肺癌,在肺癌组织中的高表达是肺癌分化差、恶性程度高的标志.

Objective To investigate Fascin expression in human lung cancer tissues and its clinical significance.Methods Immunohistochemistry was performed in 62 patients with different histological types and clinical stages of lung cancer and 92 cases with other malignant tumors.Fascin positive rate in each group was calculated and the differences of pathological characters between the two groups were analyzed.Results Fascin expression in lung cancer tissues was significantly higher than that in normal lung tissues（P 〈 0.05）,its expression varied by different clinical stage of lung cancer tissue differentiation.As differentiation degree decreased,Fascin positive rate increased.Fascin expression was independent with age,sex,smoking history（P 〉 0.05）.Fascin expression had no significant difference between lung cancer group and other tumor group（P 〉 0.05）.Conclusions Fascin expression raising might be common in malignant tumors.Fascin expression in lung tissues indicated the possibility of lung cancer.In lung tissue,high expression of Fasein was a sign of poor differentiation and malignant status of lung cancer.