子宫肿瘤患者组织和血清SOD、GSH-Px及LPO含量分析

Analysis of tissue and serum SOD and LPO content in patients with uterine tumor

目的 探讨子宫肿瘤与氧自由基的关系。方法 测定子宫良、恶性肿瘤患者瘤组织、同源瘤旁组织及对照组血清ＳＯＤ、ＧＳＨ－ ＰＸ 和ＬＰＯ 的含量。结果 子宫良性和恶性肿瘤组织中ＳＯＤ、ＧＳＨ－ Ｐｘ／ＬＰＯ 比值均明显低于同源瘤旁组织；恶性肿瘤组织中ＧＳＨ－ Ｐｘ 显著低于瘤旁组织，而ＬＰＯ增高（ Ｐ均＜ ０．００１） ，并且ＧＳＨ－ Ｐｘ／ＬＰＯ比率亦显著低于良性肿瘤组（ Ｐ＜０．００１） ；子宫恶性肿瘤组血清ＧＳＨ－ Ｐｘ／ＬＰＯ 比率明显低于良性肿瘤组和对照组（ Ｐ＜ ０ ．０１） 。结论 机体组织中ＳＯＤ、ＧＳＨ－Ｐｘ 和ＬＰＯ含量变化与子宫肿瘤的发生、发展及恶变密切关联，血清抗氧化酶水平尚不足于恶性肿瘤的早期诊断，但ＧＳＨ－ Ｐｘ／ＬＰＯ比率对子宫肿瘤的良、恶性鉴别具有重要的临床价值。

Objectives To discuss the relation between uterine tumor and SOD.Methods SOD,GSH-Px and LPO contents were detected in tumor tissue,in paratumor tissue in patients with benign or malignant uterine tumors,as well as in serum in the control group.Results SOD and GSH-Px/LPO ratio in benign or malignant uterine tumor tissue were obviously lower than that in homologous paratumor tissue.GSH-Px in malignant tumor was significantly lower than that in paratumor tissue,with increased LPO (P<0.001),and GSH-Px/LPO ratio was significantly lower than that in bening tumor group (P<0.001).Serum GSH-Px/LPO ratio in malignant tumor group was obviously lower than that in benign tumor group and control group (P<0.01).Conclusion Change of tissue SOD,GSH-Px and LPO content is closely related to the occurrence,development and cancerization of uterine tumor.The serum antioxidase level is not sufficient enough for early diagnosis of malignant tumor,while GSH-Px/LPO ratio is of great importance in the differential diagnosis of benign and malignant uterine tumors.