摘要
Helicobacter pylori (H.pylori) has co-evolved with humans to be transmitted from person to person and to colonize the stomach persistently.A well-choreographed equilibrium between the bacterial effectors and host responses permits microbial persistence and health of the host,but confers a risk for serious diseases including gastric cancer.During its long coexistence with humans,H.pylori has developed complex strategies to limit the degree and extent of gastric mucosal damage and in? ammation,as well as immune effector activity.The present editorial thus aims to introduce and comment on major advances in the rapidly developing area of H.pylori/human gastric mucosa interaction (and its pathological sequelae),which is the result of millennia of co-evolution of,and thus of reciprocal knowledge between,the pathogen and its human host.
Helicobacter pylori （H.pylori） has co-evolved with humans to be transmitted from person to person and to colonize the stomach persistently.A well-choreographed equilibrium between the bacterial effectors and host responses permits microbial persistence and health of the host,but confers a risk for serious diseases including gastric cancer.During its long coexistence with humans,H.pylori has developed complex strategies to limit the degree and extent of gastric mucosal damage and in？ ammation,as well as immune effector activity.The present editorial thus aims to introduce and comment on major advances in the rapidly developing area of H.pylori/human gastric mucosa interaction （and its pathological sequelae）,which is the result of millennia of co-evolution of,and thus of reciprocal knowledge between,the pathogen and its human host.
基金
Supported by University of Pavia(Fondo d'Ateneo per la Ricerca
to Ricci V)
Second University of Naples(CIRANAD
to Romano M)
关键词
幽门螺杆菌
胃癌
膜分子
串音
共同进化
胃粘膜损伤
免疫效应
人类
Helicobacter pylori
Gastric mucosa
Pathogen/host interaction
Gastric diseases
Bacterial virulence factors
CagA
VacA
