妊娠期肝内胆汁淤积症对围产儿结局的影响

Effect of intrahepatic cholestasis of pregnancy on perinatal outcomes

目的：探讨妊娠期肝内胆汁淤积症（ICP）对围产儿结局的影响及防治措施。方法：回顾性分析2001年2月~2009年12月ICP患者81例（观察组）的临床资料,随机选取同期分娩的无ICP正常孕产妇81例（对照组）进行对比分析,比较两组围产儿结局。结果：观察组胎儿窘迫、新生儿窒息、围产儿死亡及早产发生率均高于对照组,差异均有统计学意义（P〈0.05）。结论：ICP对围产儿结局影响极大,可引起早产、胎儿窘迫、新生儿窒息、围产儿死亡。早诊断、早治疗、加强孕产期监护,适时终止妊娠是降低其并发症的关键。

Objective：To explore the effect of intrahepatic cholestasis of pregnancy（ICP） on perinatal outcomes and the preventive and therapeutic measures.Methods：The clinical data of 81 cases with ICP（observation group） from the hospital from February 2001 to December 2009 were analyzed retrospectively,and 81 normal pregnant women without ICP（control group） at the same period were selected randomly,the perinatal outcomes in the two groups were compared.Results：The incidences of fetal distress,neonatal asphyxia and premature delivery and perinatal mortality in observation group were significantly higher than those in control group（P0.05）.Conclusion：ICP has great impact on perinatal outcomes,which can induce premature delivery,fetal distress,neonatal asphyxia and perinatal mortality.Early diagnosis,early treatment,enhancing monitoring during pregnancy and terminating pregnancy appropriately are the key points to reduce the complications.