六神软膏的研制

Study on preparation and quality control of liushen ointment

为满足临床需要，改变传统剂型。方法：对常用水溶性基质进行筛选，运用正交试验法优选基质最佳配方。采用消化后氧化－还原滴定的方法测定软膏中雄黄的含量。结果：选用甲基纤维素和丙二醇为软膏基质。制备工艺可行，制剂稳定，无刺激性。质量控制方法可靠，平均回收率为9904％，RSIJ为0.34％。结论：该制剂可用于临床。

OBJECTIVE: To satisfy the needs of clinical therapy, and improve the traditional prepartion. METHODS: Optimizatematrix composition with orthogonal design test from the popular water-soluable matrix Xionghuang in Linshen ointment was deter-mined by oxidation-reduction titration after digestion. RESULTS: Liushea Ointment was prepared with MG450 and Propylenegycol.The prepartion technique was practicable, it is stable and has no irritation. The method of content determination was reiable. Theaverage recovery is 99.04 % with RSD 0. 34 %. CONCLUSION: It may be used in clinic.