辛伐他汀对维持性血液透析患者血清白介素-6、白介素-8、肿瘤坏死因子-α水平的影响

Study on the effect of Simvastatin on serum IL-6,IL-8,and TNF-αin maintenance hemodialysis patients

【目的】观察辛伐他汀对维持性血液透析(maintenance hemodialysis,MHD)患者血清细胞炎性因子白介素-6(interleukin-6I,L-6)、白介素-8(interleukin-8I,L-8)、肿瘤坏死因子-α(tumor necrosis factor-alpha,TNF-α)的影响。【方法】选取MHD治疗的尿毒症患者80例,检测血清IL-6I、L-8、TNF-α的浓度,然后将80例患者随机分为辛伐他汀治疗组(simvastatin treatment group,S组)和非辛伐他汀治疗组(patient control group,P组),S组40例在血液透析治疗同时给予辛伐他汀治疗,P组40例单纯血液透析治疗,于6个月后再次检测S组、P组IL-6I、L-8、TNF-α值。【结果】辛伐他汀临床干预6个月后S组IL-6I、L-8、TNF-α水平较前明显下降(P<0.01);而非辛伐他汀组IL-6I、L-8、TNF-α与治疗前比较差异无统计学意义(P>0.05)。【结论】辛伐他汀可以降低MHD患者血清IL-6I、L-8、TNF-α水平,改善MHD患者微炎症状态。

[Objective] To investigate the effect of Simvastatin on serum levels of IL-6, IL-8, and TNF-α in maintenance hemodialysis（MHD） patients. [Methods] The serum IL-6, IL-8, TNF-ot levels of 80 MHD patients were detected. Then 80 MHD patients were randomly divided into Simvastatin treatment group （S group）and patient control group（P group）. 40 patients in the S group were given the treatment of homodialysis ＋ Simvastatin while 40 cases in the P group were not given the Simvastatin treatment. The levels of IL-6, IL-8 and TNF-~ of the S group and the P group were detected after 6 months of treatment. [ Results] After 6 months of treatment, IL-6, IL-8 and TNF- c~ levels of the patients in the S group were obvious decreased （P 〈0.01） as compared with those before the treatment; while the levels of those in the P group had no obvious decrease as compared with those before the treatment（P〉 0.05）. [Conclusion] Simvastatin could reduce the levels of IL-6, IL-8 and TNF-α of MHD patients, which has positive effect on the control of the microinflammatory state.