PTD介导的蛋白转导技术及其在医学领域中的应用

PTD Mediated Protein Transduction Technology and Its Application in Medical Field

生物活性的大分子物质导入细胞内部,能够最直接有效地改变细胞的状态,因而具有巨大的潜在医药价值。但是一直以来,如何将具有生物活性的大分子物质导入细胞内部始终困扰着人们,蛋白质转导域(PTD)介导的蛋白转导技术解决了这一难题。其高效的转导功能为疾病的临床治疗、治疗性蛋白药物的开发、基础医学和应用医学等领域的研究开辟了一条崭新的途径。人们已经成功地应用这一技术将多种物质导入细胞或机体的组织器官,显示了其优越的应用价值。

The delivery of bioactive macromolecular substances into cells provides an efficient approach to changing cellular conditions,and is thus of enormously potential therapeutic significance.It has also been an extremely difficult approach due the the impediment and protective nature of cell membrance until the protein transduction domain＇s（PTD＇s） capability to ferry macromolecule across cell membrance was discovered.PTD＇s efficient transductive function has rendered an exciting promise to the clinical treatment of diseases,therapeutic proteins drug development,and basic medical and applied research.The technology has been successfully applied to deliver a variety of substances into cells or tissue organs,and its superior application values have been explicitly demonstrated.