细胞移植替代肝脏移植的潜力

Potential of Cell Transplantation as an Alternative to Liver Transplantation

人肝细胞移植用于治疗肝源性代谢缺陷和急性肝衰竭已显示出在早期有望改善肝功能,但是其作为长期有效的治疗还未取得成功。运用干细胞移植替代肝脏移植来恢复人体肝功能至今也尚未成功。目前,正在将干细胞作为肝细胞移植的细胞源加以研究。肝脏的肝细胞外基质为干细胞分化成肝细胞以及细胞移植提供了理想的支架材料,新颖的肝脏脱细胞后得到肝细胞外基质的技术为肝细胞的成熟和移植提供了潜力巨大的支架材料,并促进了可移植入体内的工程再造肝脏的发展。

Human hepatocyte transplantation to treat liver-based metabolic deficiencies and acute liver failure has shown promising early improvement in liver function;however,long-term success has not been achieved.Stem cell transplantation to restore liver function as an alternative to whole liver transplantation has not been successful in humans.As alternative sources of cells for human hepatocyte transplantation,stem cells are under investigation.The liver extracellular matrix presents an ideal scaffold for stem cell differentiation into hepatocytes,as well as cell transplantation.The innovative technique of the decellularized liver matrix presents great potential as the scaffold for hepatocyte maturation and transplantation,and allows the development of engineered recellularized liver graft for transplantation.