食管癌COX-2和VEGF的表达及其与临床病理特征的关系

Expressions of COX-2 and VEGF in esophagus carcinoma and their relationships with clinical pathologic characteristics

目的探讨COX-2、VEGF在食管癌组织中的表达及其与食管癌临床病理特征的相关性及两者关系。方法免疫组化方法检测68例手术切除的食管癌组织中COX-2、VEGF的表达,分析两者表达与食管癌临床病理特征的相关性及两者关系。结果 COX2和VEGF在正常食管组织中未见表达或很少表达,而在食管癌组织中COX-2阳性率79.4%;VEGF-C阳性率72.1%。食管癌的分化程度越低,COX-2的表达越高,两者有明显相关性,P<0.05;但VEGF的表达与分化程度无明显相关性,P>0.05。COX-2、VEGF的表达均随浸润深度增加而逐渐增加,两者均呈正相关,P<0.05;两者在无淋巴结转移的食管癌组织中的表达均明显低于有淋巴结转移及远处转移者(P<0.01),两者呈正相关。同样,COX-2、VEGF的表达与TNM分期相关。结论 COX-2、VEGF在食管癌中呈高表达状态,并且这种高表达与食管癌的病理特征包括分化程度、浸润深度、淋巴结转移及TNM分期相关,COX-2与VEGF的表达与食管癌的浸润深度、淋巴结转移及TNM分期的关系呈正相关。

Objective To explore the expressions of COX-2 and VEGF in esophagus carcinoma and their relationships with clinical pathologic characteristics.Methods The expressions of COX-2 and VEGF in 68 patients who underwent surgical resection of esophagus carcinoma were detected by immunohistochemistry and their relationships with clinical pathologic characters were analyzed.Results The expressions of COX-2 and VEGF in normal esophagus tissue were few,however,the positive rates of COX-2 and VEGF in esophagus carcinoma were 79.4% and 72.1%.The differentiate degree was correlated with the expression of COX-2,the lower the differentiate degree,the higher the expression of COX-2,P〈0.05;but the differentiate degree was not correlated with the expression of VEGF,P〉0.05.The expressions of COX-2 and VEGF were positively correlated with the infiltration depth and lymph node metastasis（P〈0.05）,their expressions were obviously lower in esophagus carcinoma without lymph node metastasis than in esophagus carcinoma with lymph node metastasis（P〈0.01）.Moreover,the expressions of COX-2 and VEGF were correlated with TNM grade.Conclusion The expressions of COX-2 and VEGF in esophagus carcinoma were higher than those in normal tissue.The expressions of COX-2 and VEGF were positively correlated with the infiltration depth,metastasis and TNM grade.