新辅助化疗联合放疗治疗局限性晚期宫颈癌的临床疗效观察

Curative effect of neoadjuvant chemotherapy combined with radiotherapy on patients with advanced cervical cancer

目的分析新辅助化疗联合放疗治疗局限性晚期宫颈癌的有效性与安全性。方法临床收集84例局限性晚期宫颈癌患者,随机分成2组,对照组(44例)采用新辅助化疗方法治疗,治疗组(40例)均采用新辅助化疗联合放疗治疗,疗程结束后比较并评价两种治疗方法的有效性与安全性。结果治疗后临床观察结果显示,新辅助化疗联合放疗治疗局限性晚期宫颈癌近期观察是安全和有效的,有效率达到95%,与单纯新辅助化疗组相比具有显著的统计学差异(P<0.05)。结论新辅助化疗联合放疗治疗局限性晚期宫颈癌是有效的,同时具有很好的耐受性。

Objective To analyze the feasibility and safety of neoadjuvant chemotherapy combined with radiotherapy for patients with advanced cervical cancer.Methods Eighty-four patients with advanced cervical cancer were enrolled and divided into treatment group（n=40） and control group（n=44）.The patients in treatment group received neoadjuvant chemotherapy combined with radiotherapy while those in control group received neoadjuvant chemotherapy only.The feasibility and safety of two treatment methods were evaluated after the therapy finished.Results The results showed that neoadjuvant chemotherapy combined with radiotherapy was safe and feasible for patients with advanced cervical cancer,the curative rate amounting to 95%,markedly different from that in control group（P0.05）.Conclusion Neoadjuvant chemotherapy with radiotherapy is effective with tolerable toxicities in the treatment of advanced cervical cancer.