宫颈环形电切除术对治疗宫颈上皮内瘤变的临床观察

Clinical Effects of Loop Electrosurgical Excision Procedure in the Treatment of Cervical Intraepithelial Neoplasia

目的探讨宫颈环形电切除术(LEEP)在宫颈上皮内瘤变(CIN)治疗的临床价值.方法对2006年8月至2009年8月经阴道镜下宫颈活检诊断为CIN的206例患者采用LEEP宫颈锥切,观察患者自觉症状、手术时间、出血量,比较术前宫颈活检与术后病理检查结果、随访疗效和宫颈恢复情况.结果 LEEP治疗CIN平均时间11 min,出血量16 mL,阴道镜下宫颈活检的CINI、CINⅡ、CINⅢ与LEEP术后差异有统计学意义(P<0.01),治愈率为98.06%,206例中宫颈塑形满意178例(86.41%).结论 LEEP是诊断和治疗CIN安全有效的方法.

Objective To study the clinical value of loop electrosurgical excision procedure （LEEP） in the treatment of cervical intraepithelial neoplasia （CIN）. Methods LEEP was performed in 206 cases of CIN after multiple punch biopsy under colposcopy treatment in our hospital between August 2006 and August 2009. The symptoms, operative time, volume of bleeding of patients were observed and compared with preoperative cervical biopsy and postoperation pathological examination findings, and patients were followed up to observe the cervical recovery. Results The average time of LEEP was 11 minutes, the volume of bleeding was 16 mL. CIN I, CIN Ⅱ , CIN Ⅲwith colposcopic cervical biopsy and CIN I, CIN Ⅱ , CINⅢ with LEEP of post operation pathologic diagnosis were positive correlated, the correlation coefficient was 0.763 （P 〈 0.01 ）. The cure rate ot LEEP was 98.06%, 178 cases of 206 with shaping of cervical specimens were satisfied （86.41%）. Conclusior LEEP is a safe and effective method for diagnosis and treatment of CIN.