^99Tc^m—TRODAT-1脑SPECT用于体质指数与纹状体多巴胺转运蛋白相互关系的研究

The relationship between BMI and striatal dopamine transporter with ^99Tc^m-TRODAT-1 brain SPECT

目的 探讨BMI与人脑纹状体DAT的相互关系及对99Tcm-TRODAT-1脑SPECT显像的影响.方法 31名健康志愿者（男16名,女15名）分别进行颅脑MRI和99Tcm-TRODAT-1脑SPECT显像.对SPECT图像进行三维重建,参照MRI图像,在SPECT图像横断面纹状体（ST）显示最清楚的连续4层图像上对脑左、右ST（LST、RST）分别进行ROI勾画,取小脑（CB）作为本底参考区,分别计算ST/CB、LST/CB和RST/CB的放射性摄取比值.采用SPSS 15.0软件,分别对ST/CB、LST/CB、RST/CB与BMI、年龄进行Pearson相关性分析;然后以BMI、年龄为自变量,ST/CB为因变量进行多因素回归分析.结果 31名健康志愿者99Tcm-TRODAT-1脑SPECT显像示双侧ST左右对称,放射性前部高于后部.其ST/CB、LST/CB和RST/CB的平均值分别为1.71±0.16,1.70±0.16和1.72±0.17;女性ST/CB、LST/CB和RST/CB的平均值分别为1.74±0.18,1.71±0.19和1.76±0.19;男性ST/CB、LST/CB和RST/CB的平均值分别为1.68±0.14,1.68±0.13和1.69±0.15.ST/CB、LST/CB和RST/CB与BMI均呈负相关（r=-0.53,-0.57,-0.47,P均＜0.05）.ST/CB与年龄呈负相关（r=-0.39,P=0.03）.多因素回归分析发现仅BMI为显著影响因素（回归系数β=-0.53,t=-3.36,P=0.002）.结论 健康人脑ST DAT水平随着BMI、年龄的增高而呈降低趋势.女性STDAT水平略高于男性.提示在99Tcm-TRODAT-1脑SPECT显像中,不但要考虑年龄、性别等影响因素,而且要注意BMI也是重要影响因素.

Objective To assess the relationship between the BMI and the brain DAT, and the influence of BMI on the brain SPECT imaging with 99Tcm-TRODAT-1. Methods MRI and 99Tcm-TRODAT-1SPECT imaging were performed in 31 healthy volunteers（16 males and 15 females）, and then the three-dimensional reconstruction of SPECT images were completed. Based on the MRI images, right striatum （RST） and the left striatum （LST） were drawn as ROI on the 4 most clearly consecutive transverse slices.The cerebellum （CB） was taken as the background reference area and the corresponding uptake ratios of ST/CB, LST/CB and RST/CB were calculated. The Pearson correlation tests for radio-uptake ratios （ST/CB, LST/CB, RST/CB）, BMI and age were performed, Then multiple linear regression analysis using ST/CB as dependent variable and BMI and age as independent variables was performed. SPSS 15.0 was used in data analysis. Results The ST imaging was symmetrical. The radioactivity was higher in the ST front area than that of the back area. The average uptake ratios of ST/CB, LST/CB, RST/CB were 1.71±0.16,1.70 ± 0. 16 and 1.72±0.17 respectively, in which the three ratios of the female were 1.74 ± 0. 18, 1.71±0. 19 and 1.76 ± 0. 19 respectively and those of the male were 1.68 t 0. 14, 1.68 ± 0. 13 and 1.69± 0.15respectively. ST/CB, LST/CB and RST/CB were negatively correlated with patients＇BMI （r = -0. 53,-0.57,-0.47, all P〈0.05）. The ST/CB was negatively correlated with patients＇ age（r=-0.39, P=0. 03）. The multiple linear regression analysis showed that the BMI was significant independent variable （β=-0.53, t= -3.36, P=0. 002）. Conclusions TheSTDAT,evel may decrease as patients＇ BMI and age increase. Females＇ DAT level is slightly higher than males＇. For ST DAT imaging, age, gender and BMI should be all taken into consideration.