冠心病患者载脂蛋白AV与脂蛋白(a)关系研究

The correlation between serum concentrations of apolipoprotein AV and level of Lipoprotein(a) in patients with coronary heart disease

目的:探讨冠心病患者血清载脂蛋白AV(ApoAV)与脂蛋白(a)[LP(a)]之间的关系。方法:入选120例住院患者均接受冠状动脉造影检查,根据造影结果分为冠心病组60例和对照组60例,所有患者均测定空腹血糖(FBG)、血清TC、TG、HDL-C、LDL-C、载脂蛋白A1(ApoAI)、载脂蛋白B(ApoB)与LP(a);同时采用酶联免疫吸附法测定血清ApoAV。所有资料均进行正态性检验。结果:冠心病组血清ApoAV、ApoAI、HDL-C显著低于对照组[(206.76±135.95)μg/L∶(265.33±122.35)μg/L],[(1.09±0.26)g/L∶(1.23±0.25)g/L],[(1.22±0.29)mmol/L∶(1.31±0.21)mmol/L],P<0.01;TG、LP(a)高于对照组[(1.64±1.15)mmol/L∶(1.10±0.37)mmol/L],[(393.03±280.08)mg/L∶(218.37±60.58)mg/L],P<0.01。ApoAV与TG、LP(a)呈负相关,与HDL-C呈正相关。结论:冠心病患者血清ApoAV降低、LP(a)增高。ApoAV与LP(a)对冠心病的发展影响不同。

Objective：To explore The correlation between serum concentrations of apolipoprotein AV and level of Lipoprotein（a） in patients with coronary heart disease（CHD）.Method：The level of serum total cholesterol（TC）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,apolipoprotein A1（ApoA1）,apolipoprotein B（ApoB） and Lipoprotein（a） were examined in 120 individuals by biochemistry department;enzyme-linked immunosorbent assay（ELISA） method was used to determine ApoAV.All individuals underwent coronary angiography were divided into two groups： 60 patients with CHD and 60 control individuals.Result：The concentrations of ApoAV,ApoAI and HDL-C in CHD groupswere significantly lower than the control groups [（206.76±135.95）μg/L vs（265.33±122.35）μg/L],[（1.09±0.26）g/L vs（1.23±0.25）g/L],[（1.22±0.29）mmol/L vs（1.31±0.21）mmol/L],P0.01;whereas TG and LP（a） levels were significantly higher than the control groups [（1.64±1.15）mmol/L vs（1.10±0.37）mmol/L],[（393.03±280.08）mg/L vs（218.37±60.58）mg/L],P0.01.Serum ApoAV was negatively correlated with TG and LP（a）,but positively correlated with HDL-C.Conclusion：The patients with CHD have decreased serum levels of ApoAV and HDL-C,but increased levels of TG and LP（a）.ApoAV and LP（a） have different influence in the development of CHD.