摘要
AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk. METHODS: A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer. RESULTS: The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively). CONCLUSION: This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.
AIM： To explore the association between single nucleotide polymorphisms （SNPs） at 8q24 and gastric cancer risk. METHODS： A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs （rs6983267, rs7008482 and rs10808555） were examined and established through polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP）. Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer. RESULTS： The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control （P = 0.005）. GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype （adjusted odds ratio = 2.01, 95% confidence interval： 1.28-3.14）. Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type （OR： 2.638, 95% CI： 1.464-4.753; OR： 1.916, 95% CI： 1.166-3.150, respectively）. CONCLUSION： This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.
基金
Supported by Shanghai "Phosphor" Science Foundation, China, No. 09QB1403100
the National High Technology Researchand Development Program of China, No. 2006AA020704 and 2006AA02A407
the Funds for Key Programs of Ministry ofHealth of China, No.2008ZX10002-017
