精液处理后活动精子总数对宫腔内人工授精妊娠率的影响

Effect of the Processed Total Motile Sperm Count on the Success of Intrauterine Insemination

目的:探讨精液处理后活动精子总数(PTMS)对宫腔内人工授精(IUI)妊娠成功率的影响。方法:回顾性分析372例不孕患者共816个IUI周期的临床资料。按照PTMS数量将IUI周期分成4个区间组:PTMS<3×106(A组),3×106-5×106(B组),5×106-10×106(C组),>10×106(D组),分别比较各组间的IUI周期妊娠率。结果:816个IUI周期共获得110例妊娠,总周期妊娠率为13.5%。不同PTMS分组的周期妊娠率分别为3.8%,4.2%,14.8%和14.3%。其中A组、B组的周期妊娠率均显著低于C组和D组(P<0.05)。结论:PTMS是男性生育力评估及助孕方式选择的重要参考依据。当PTMS超过5×106时,可首选IUI治疗。

Objective：To assess the relationship between the processed total motile sperm（PTMS） count and intrauterine insemination（IUI） outcome.Methods：The clinical data of 372 infertile couples who underwent 816 IUI cycles was analyzed by a retrospective study.According to the PTMS count,the patients were divided into 4 groups：3×106（group A）,3×106 to 5×106（group B）,5×106 to 10×106（group C） and 10×106（group D）.The difference of pregnancy rate per cycle among the subgroups was then compared by statistical analysis.Results：A total of 110 clinical pregnancies were obtained and the overall pregnancy rate was 13.5% per cycle.The pregnancy rate of each group was 3.8%,4.2%,14.8% and 14.3%,respectively.The pregnancy rate per cycle in groups A or group B was significantly lower than that in groups C and D（P0.05）.Conclusion：PTMS assay is an important reference for male fertility assessment and the choice of assisted reproductive technology.In our opinion,IUI treatment is recommended to be performed when PTMS is 5×106.