低频共振对大鼠生理功能影响研究

Effects of low frequency resonance on physiological function in rats

目的研究持续低频共振条件下大鼠血压、心率、呼吸频率和体温等生理指标变化特点,为生物体器官共振损伤及其反应研究奠定基础。方法 SD大鼠32只,随机分为假振动组、3 Hz频率振动组、6 Hz频率振动组和21 Hz频率振动组1,.5%戊巴比妥钠麻醉后,行股动脉插管,然后将大鼠以仰卧姿固定在振动台上,静置30 min以后,振动组施加振幅(p-p)为5 mm正弦振动,观测振动之前和振动1,3,5,10,30,601,20,1802,40,3003,60 min的血压、心率、呼吸频率、体温等生理指标,假振动组观测相应时间点的上述生理指标。结果持续低频共振会引起大鼠的血压、心率、呼吸频率在振动1 min时迅速升高,1～3 min达到最大值,之后逐渐下降3,0 min后低于正常值,而在振动初期共振不会对大鼠体温造成影响,体温在振动10 min之后才缓慢降低。在振动初期6 Hz频率共振对大鼠血压、心率、呼吸频率的影响比较大,而在后期3 Hz频率共振影响比较大。但这2个频率的共振对大鼠体温的影响是一致的。结论持续低频共振会引起大鼠的血压、心率、呼吸频率先迅速升高后逐渐降低,还会造成大鼠体温调节能力下降。

Objective To study the effect of continuous low frequency resonance on blood pressure,heart rate,breath rate and body temperature of the rat so as to provide basic data for the study of organs’resonance injury and its reaction.Method Thirty-two SD rats were divided into four groups randomly： false vibration group,3 Hz vibration group,6 Hz vibration group and 21 Hz vibration group.Femoral artery intubatton was given after anaesthesia with 1.5% sodium pentobarbital.All the rats were fastened on their back on the vibration platform staying calmly for 30 min.Then the vibration groups were given sine wave vibration with 5 mm amplitude（p-p）,while the blood pressure,heart rate,breath rate and body temperature of the rats were measured at 0,1,3,5,10,30,60,120,180,240,300 and 360 min.The above physiological data were also observed in false vibration group at corresponding time.Results Continuous low frequency resonance could cause the blood pressure,heart rate,breath rate of the rat to rise rapidly after 1 min of vibration,and to reach the maximum value after 1 min to 3 min of vibration,and then to descend gradually and to be lower than the normal value after 30 min of vibration.The body temperature of the rat did not change at the beginning of vibration,but descended gradually after 10 min of vibration.At the beginning of vibration,the effect of 6 Hz resonance on blood pressure,heart rate,breath rate was dominating,while at the later stage,3 Hz resonance was dominating.But the effect of the two frequencies on body temperature was accordant.Conclusions Continuous low frequency resonance can cause the blood pressure,heart rate,breath rate of the rat to rise rapidly at the beginning of vibration and then to descend gradually,and it can also depress the ability of body temperature regulation in rats.