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CD147、MMP-2 mRNA在胃癌组织中的表达及临床意义 被引量：3

The expression and clinical significance of the CD147 and MMP-2 mRNA in gastric carcinoma
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摘要 目的探讨CD147及基质金属蛋白酶-2(MMP-2)mRNA在胃癌组织中的表达及其意义。方法应用原位杂交方法检测76例石蜡包埋胃癌组织及20例癌旁正常胃黏膜中CD147和MMP-2 mRNA的表达情况。结果 CD147和MMP-2 mRNA在胃癌组织中的阳性表达率分别为69.7%、75.0%,与癌旁正常胃黏膜比较差异均有统计学意义(P<0.01)。CD147和MMP-2 mRNA阳性表达与肿瘤的大小、浸润深度、淋巴结转移有关(P<0.05),与患者的性别、年龄、肿瘤的分化程度无关。CD147和MMP-2 mRNA在胃癌组织中的表达具有相关性(P<0.01)。结论 CD147和MMP-2 mRNA的表达与胃癌的浸润和转移有关,可以作为胃癌进展和预后的指标。 Objective To investigate the significance of CD147 and matrix metalloproteinase-2（MMP-2） mRNA expression in human gastric carcinoma.Methods CD147 and MMP-2 mRNA expression was assessed in paraffin-embedded specimens collected from 76 cases of gastric carcinoma and 20 cases of adjacent normal tissues by in situ hybridization methods.Results The positive rate of expression of CD147 and MMP-2 mRNA in gastric carcinoma was 69.7%,75.0%,respectively.The expression of CD147 and MMP-2 mRNA was both strongly related to the tumor size,depth of invasion and lymph nodes metastasis of gastric carcinoma（P〈0.05）.However,CD147 and MMP-2 mRNA had no significant difference with pathological grades,age and gender.There was a significant relationship between expressions of CD147 and MMP-2 mRNA（P〈0.01）.Conclusion CD147 and MMP-2 play an important role in the invasion and metastasis in gastric carcinoma.They might be good markers for development and prognosis of gastric carcinoma.
作者 赖丽琴 张红 吴倩 秦蓉
机构地区 安徽医科大学病理学教研室
出处 《安徽医科大学学报》 CAS 北大核心 2011年第5期416-419,共4页 Acta Universitatis Medicinalis Anhui
基金 安徽省教育厅自然科学基金(编号:2005KJ259)
关键词 胃肿瘤 抗原 CD147 基质金属蛋白酶2 原位杂交 gastric carcinoma antigens CD147 matrix metalloproteinase 2 in situ hybridization
分类号 R735.2 [医药卫生—肿瘤] R345 [医药卫生—基础医学]
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参考文献12

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二级参考文献22

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共引文献13

同被引文献26

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安徽医科大学学报
2011年 第5期

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