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胃泌素释放肽受体在鳞状细胞癌中的检测及临床意义 被引量：5

Detection of GRPR in Squamous Cell Carcinoma
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摘要 目的检测鳞状细胞癌(squamous cell carcinoma,SCC)中的胃泌素释放肽受体(gastrin releasing peptide receptor,GRPR)探讨其与SCC分化程度的关系。方法用免疫组化(SP)法检测10例正常皮肤组织及46例不同分化程度SCC中GRPR的表达。结果 SCC组中33例(71.74%)阳性表达,正常皮肤组织中3例(30.00%)阳性表达,两组间GRPR的表达差异有统计学意义(P=0.022);高、中、低分化组中阳性表达分别为14例(70.00%)、9例(75.00%)、10例(71.43%),不同分化程度SCC组间GRPR的表达差异无统计学意义(P=0.916)。结论 GRPR在SCC及正常皮肤中均有表达,但在SCC中的表达高于正常皮肤,其表达与SCC的侵袭性无相关性。 Objective To investigate the expression of GRPR （gastrin-releasing peptide recepter） in different grade of squamous cell carcinoma. Methods The expression of GRPR in 10 normal skin specimens and 46 SCC specimens was detected by immunohistochemistry （SP method）. Results Thirty three （71.74%）of SCC specimens and 3 （ 30.00% ） of normal skin showed positive expression with significant differences （ P = 0.022）. Of all positive SCC, 14 （ 70.00% ） were in well-differentiated group, 9 （ 75.00% ） in moderatelydifferentiated group, and 10（71.43% ）in poorly-differentiated group. No significant differences among different degree of SCC were detected （P = 0. 916）. Conclusion GRPR were expressed in both SCC and normal skin, but the expression of GRPR in SCC was higher than that in normal skin, and there were no significant relationship between the expression of GRPR and grade of SCC.
作者 王建军 张晓鸣 张军 翟学锋 尚元元
机构地区 宁夏医科大学附属医院皮肤科 宁夏医科大学附属医院病理科
出处 《中国皮肤性病学杂志》 CAS 北大核心 2011年第5期341-343,共3页 The Chinese Journal of Dermatovenereology
关键词 胃泌素释放肽受体 鳞状细胞癌 免疫组化 GRPR Squamous cell carcinoma Immunohistochemistry
分类号 R739.5 [医药卫生—肿瘤]
  • 相关文献

参考文献14

  • 1Lango MN, Dyer KF, Lui VW, et al. Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the headand neck[ J]. J Natl Cancer Inst, 2002, 94 (5) : 375 -383.
  • 2朱学骏,孙建方.皮肤病理学与临床的联系[M].3版.北京:北京大学医学出版社,2006:1204-1206.
  • 3Handel ML, Mcmorrow LB, Gravallese EM. Nuclear factor kappaB in rheumatoid synovium. Localization of p50 anti p65 [ J ]. Arthritis Rheum, 1995,38(12) :1762 - 1770.
  • 4Jensea RT, Bauey JF, Spindel ER, et al. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling and functions in normal and disease states[J]. PharmacolRev, 2008, 60(1): 1 -42.
  • 5Baldwin GS, Patel O, Shulkes A. Phylogenetic analysis of the sequences of gastrin-releasing peptide and its receptors:biological implications[J]. RegulPept, 2007, 143(1 -3):1-14.
  • 6赵开军(综述),沈建康,孙青芳(审校).胃泌素释放肽受体在肿瘤中分布的临床意义[J].国际肿瘤学杂志,2008,35(9):660-664. 被引量：4
  • 7赵开军,沈建康.胃泌素释放肽受体在肿瘤治疗中的研究进展[J].世界华人消化杂志,2009,17(1):63-67. 被引量：11
  • 8Perona R. Cell signalling: growth factors and tyrosine kinase receptors [J]. Clin Transl Oneol, 2006, 8(2) : 77 -82.
  • 9Salido M, Vilches J, Lopez A, et al. Neuropeptides bombesin and calciton in inhibit apoptosis-related elemental changes in prostate carcinoma cell lines [ J ].Cancer, 2002, 94 (2) : 368 - 377.
  • 10Lui VW, Thomas SM, Zhang Q, et al. Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor [ J ]. Oncogene, 2003, 22(40) :6183 -6193.

二级参考文献66

  • 1Perona R. Cell signaling: growth factors and tyrosine kinase receptors. Clin Transl Oncol, 2006,8(2) :77-82.
  • 2Jensen RT, Battey JF, Spindel ER, et al. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacol Rev, 2008, 60( 1 ) : 1-42.
  • 3Fleischmann A, Laderach U, Friess H, et al. Bombesin receptors in distinct tissue compartments of human pancreatic diseases. Lab Invest, 2000, 80 ( 12 ) : 1807-1817.
  • 4de Visser M, van Weerden WM, de Ridder CM, et al. Androgen- dependent expression of the gastrin-releasing peptide receptor in human prostate tumor xenografts. J Nucl Med, 2007, 48( 1 ) :88-93.
  • 5Sakamoto H, Matsuda K, Zuloaga DG, et al. Sexually dimorphie gastrin releasing peptide system in the spinal cord controls male reproductive functions. Nat Neurosci, 2008, 11 (6) :634-636.
  • 6Fleischmann A, Waser B, Reubi JC. Overexpression of gastrin- releasing peptide receptors in tumor-associated blood vessels of human ovarian neoplasms. Cell Oncol, 2007, 29 (5) : 421-433.
  • 7Chave HS, Gough AC, Palmer K, et al. Bombesin family receptor and ligand gene expression in human colorectal cancer and normal mucosa. Br J Cancer, 2000, 82(1 ) : 124-130.
  • 8Taglia L, Matusiak D, Benya RV. GRP-induced up-regulation of Hsp72 promotes CD16 +/94 + natural killer cell binding to colon cancer ceils causing tumor cell cytolysis. Clin Exp Metastasis, 2008,25(4):451-463.
  • 9Heuser M, Schlott T, Schally AV, et al. Expression of gastrin releasing peptide receptor in renal cell carcinomas : a potential function for the regulation of neoangiogenesis and microvascular perfusion. J Urol, 2005, 173(6) :2154-2159.
  • 10Nisman B, Heching N, Biran H, et al. The prognostic significance of circulating neuroendocrine markers chromogranin a, progastrin- releasing peptide and neuron-specific enolase in patients with advanced non-small-cell lung cancer. Tumour Biol, 2006, 27 (1) :8- 16.

共引文献11

同被引文献38

  • 1Perona R. Cell signalling: growth factors and tyrosine kinase recep- tors[J]. Clin Transl Onco1,2006,8: 77-82.
  • 2Baldwin GS, Patel O, Shulkes A. Phylogenetic analysis of the se- quences of gastrin-releasing peptide and its receptors: bio-logical implications[J]. Regul Pept, 2007,143 ( 1-3 ) : 1-14.
  • 3Cassano G,Resta N,Gasparre G,et al. The proliferative response of I-IT-29 human colon adenocarcinoma cells to bombesinlike peptides[J]. Cancer Lett, 2001,172 (2) : 151 - 157.
  • 4Scott N ,Millward E ,Cartwright EJ,et al. Gastrin releas- ing peptide and gastrin releasing peptide receptor expres- sion in gastrointestinal carcinoid tumours[J]. J Clin Pathol, 2004,57 (2) : 189-192.
  • 5Sexton M,Jones DB,Maloney ME.Histologic pattern analysis of basal cell carci-noma study of a series of 1038 consecutive neoplasms[J].J Am Acad Dermatol,1990,23(6):1118.
  • 6Milroy C J,Richman PI,Wilson GD,et al.Reporting basal cell carcinoma a survey of the attitudes of histopathologists[J].J Clin Pathol,1999,52(11):867.
  • 7Handel ML,Mcmorrow LB,Gravallese EM.Nuclear factor kappa B in rheumatoid synovium.Localization of p50 and p65[J].Arthritis Rheum,1995,38:1762-1770.
  • 8Fleischmann A,Waser B,Renbi JC.Overexpression of gastrin-releasing peptide receptor in tumor-associated blood vessels of human ovarian neoplasms[J].Cell Oncol,2007,29 (5):421-433.
  • 9Brash DE,Ziegler A,Jonason AS,et a1.Sunlight and sunburn human skin cancer p53 apoptosis and tumor promotion[J].J invest Dermatol Symp Proc,1996,1 (2):136.
  • 10Chatzistamou I,SchaUy AV,Sun B,et al.Inhibition of growth of OV-1063 human epithelial ovarian cancers and c-jun and c-fos oncogene expression by bobesin antagonists[J].Br J Cancer,2000,83:906.

引证文献5

二级引证文献3

中国皮肤性病学杂志
2011年 第5期

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