308nm准分子激光联合吡美莫司软膏治疗白癜风临床观察

Combination Therapy of 308nm Excimer Laser and Topical Pimecrolimus in the Treatment of Vitiligo

目的评价308nm准分子激光联合吡美莫司软膏治疗白癜风的疗效和安全性。方法将150例白癜风患者随机分成3组。治疗组50例,308nm准分子激光(2次/周)联合吡美莫司软膏(2次/d)治疗,疗程12周。对照1组50例,单纯予308nm准分子激光治疗,用法同上。对照2组50例,单纯予吡美莫司软膏治疗,用法同上。结果治疗组有效率88.00%,对照1组为70.00%,对照2组为42.00%。治疗组和对照1组及对照2组比较,有效率差异有统计学意义(P<0.05)。治疗组皮损位于面颈部、躯干和四肢者疗效优于对照组(P<0.05),3组肢端皮损疗效差异无统计学意义(P>0.05)。患者均未出现严重不良反应。结论 308nm准分子激光联合吡美莫司软膏治疗位于面颈部、躯干和四肢的白癜风起效快,疗效好,不良反应少。

Objective To evaluate the efficacy and safety of combination therapy of pimecrolimus and 308nm excimer laser in the treatment of vitiligo. Methods One hundred and fifty patients of vitiligo were divided into three groups randomly. Fifty patients in treatment group were treated twice daily with pimecrolimus ointment combined with 308nm exeimer laser twice weekly for 12 weeks. Similarly, 50 patients in control group 1 were only treated with 308nm excimer laser twice weekly for 12 weeks and 50 patients in control group 2 were only treated with pimecrolimus ointment twice daily for 1：2 weeks. Results The total effective rate was 88.00% , 70.00% and 42.00% in treatment groupm, control 1 and 2 respectively, which showed significant difference among three groups（P 〈 0.05 ）. The effect on face, neck, trunk and extremities was better in treatment group than in control group （P 〈 0. 0.5 ）. However, there were no statistical significanee among three groups in the effective rate of acral lesions（ P 〉 0.05 ）. No serious adverse events were recorded in three groups. Conclusion The combination of pimecrolimus ointment with 308nm excimer laser can represent an effective and well-tolerated therapy for vitiligo with face neck trunk and extremities in- volved.