环状弹性纤维溶解性巨细胞肉芽肿1例

A Case of Annular Elastolytic Giant Cell Granuloma

患者女,54岁。额头、颈部、双手背部环状皮损半年余。皮肤科情况:额头、颈部、双手背部,可见数个环状皮损连结成片,形状不规则,大小不等,大者直径约3cm,小者黄豆大小,色淡红,边界较清晰、略隆起、呈堤坝状、无脱屑。皮损组织病理示:真皮内可见弹性纤维变性、碎裂,并可见巨噬细胞吞噬变性弹性纤维现象。诊断:环状弹性纤维溶解性巨细胞肉芽肿。

A 54-year-old female presented with a 6-month history of asymptomatic centrifugal annular lesions on the forehead, neck and both dorsal manus. Skin examination showed several irregular, different sizes （the biggest diameter was 3cm, the smallest was soybean sized）, reddish annular lesions with elevated borders and no scale, which tended to coalesce into flakiness on the forehead, neck and both dorsal manus. Skin biopsy showed that elastic fibers in the dermis were decreased in amount and fragmented, where muhinueleated giant cells phagocytosed fragmented elastic fibers. Diagnosis of annular elastolytic giant cell granuloma was made.