针刺治疗急性脑出血机制研究的现状分析

Progress of Researches on Mechanism of Acupuncture Therapy Underlying Improvement of Acute Cerebral Hemorrhage

本文从作用机制和研究方法两个方面,介绍了近年来针刺治疗急性脑出血机制的研究进展。针刺对脑出血病理过程的干预作用主要体现在减轻血凝块的毒性作用,减轻自由基、兴奋性氨基酸对神经细胞的损害,平衡血管活性物质的释放从而增加脑血流量,促进血肿吸收、细胞修复和神经再生等多个环节。同时,回顾了在该领域研究中针刺手法和研究手段的发展过程。提出该方面的实验研究虽然取得了一定的进展,但是还存在静态性、孤立性和辨病不辨证等问题,指出活体、无创的研究方法将是未来针刺治疗脑出血作用机制研究的趋势。

In the present paper, the authors review the progress of researches on the mechanism of acupuncture therapy underlying improvement of acute cerebral hemorrhage from experimental studies and research methods. The effects of acupuncture intervention mainly involve 1 ） lessening inflammatory reactions, 2） reducing impairment of free radicals and excitatory amino acids on cerebral neurons, 3） balancing release of vascular bioactive substances to increase regional cerebral blood flow, and 4） promoting repair and regeneration of the neural tissue, etc. In regard to the research methods, many new biological techniques such as biological molecular approaches, neuro-cellular chemical methods, reverse transcription-polymerase chain reaction （RT-PCR） or quantitative real time-PCR, situ hybridization, western blotting, electron microscope, etc., have been extensively applied to researches on the underlying mechanism of acupuncture therapy for cerebral infarction. In addition, the authors also pointed out that in spite of achieving some bigger progresses in experimental studies, most of the results basically reflect static, isolated and regional changes rather than dynamic and whole body changes. For this reason, more vivo research techniques and noninvasive research methods are highly recommended to be used in the future research on the underlying mechanisms of acupuncture therapy for acute cerebral ischemia.