三聚氰胺妊娠期给药对胎鼠肾发育影响的病理学观察

Pathobioiogical Observation on Effect of Melamine on Renal Development in Neonatal Rat

目的 观察不同剂量三聚氰胺对初生大鼠肾的影响.方法 56只雌鼠随机分成7组.实验组（M1-M6）从妊娠第一天开始每天灌服浓度为120、240,360、480、600、720 mg/kg三聚氰胺,对照组（M0）同期灌服蒸馏水,大鼠出生12 h后取肾组织进行病理学观察.结果 对照组肾脏无明显病理改变,实验组：M1与M2组肾组织病理变化不明显,M3组以肾小球和间质毛细血管扩张出血为主;M4组有明显的组近曲小管严重水肿;M5组集合管和肾盂中有大量血细胞;M5和M6组仔鼠肾髓质间质中出现纤维增生,M6组仔鼠肾髓质可见大量成纤维细胞.结论 三聚氰胺可以通过胎盘屏障,导致孕期初生大鼠肾病理性改变,且存在剂量依赖性.

Objective To observe the effect of melamine with different dosages on renal development in neonatal rats. Methods Fifty-six SD rats were randomly divided into 7 groups, groupM1- groupM6, fed with different dosages of melamine from the start of pregnancy, group M0 fed with distilled water at the same time. All neonatal rats on group M0 to M6 were sacrificed at the time of 12 h after deliver for conducting pathological examination on the kidneys. Results Compare to the control group （M0）, the experimental groups showed different pathological changes with the different dosage of melamine. Conclusion By going through the placental barrier melamine could have a pathological effect on fetus kidney during pregnancy, and the degree of the effects relies on the dosage level of melamine.