摘要
AIM:To evaluate the efficacy and safety of cetuxim-ab plus irinotecan in irinotecan-refractory metastatic colorectal cancer (mCRC) patients from South-East Asia and Australia. METHODS:In this open-label,phase Ⅱ study,the main eligibility criteria were epidermal growth factor receptor-positive mCRC with progressive disease within 3 mo of an irinotecan-based regimen as the most recent chemotherapy. Patients received cetuximab 400 mg/m2 initially,then 250 mg/m2 every week,with the same regimen of irinotecan on which the patients had progressed (4 pre-defined regim-ens allowed). The prim-ary objective was evaluation of progression-free survival (PFS) at 12 wk. Secondary objectives included a further investigation of PFS,and an assessment of the overall response rate (ORR),duration of response,time to treatment failure (TTF),overall survival and the safety profile. RESULTS:One hundred and twenty nine patients were enrolled from-25 centers in the Asia-Pacific region and of these 123 received cetuximab plus irinotecan. The most common recent irinotecan regimen used was 180 mg/m2 every 2 wk which had been used in 93 patients (75.6%). The PFS rate at 12 wk was 50% (95% confidence interval (CI,41-59) and m-edian PFS tim-e was 12.1 wk (95% CI:9.7-17.7). The ORR was 13.8% (95% CI:8.3-21.2) and disease control rate was 49.6% (95% CI:40.5-58.8). Median duration of response was 31.1 wk (95% CI:18.0-42.6) and median overall survival was 9.5 mo (95% CI,7.5-11.7). The median TTF was 11.7 wk (95% CI:9.1-17.4). Treatment was generally well tolerated. The most common grade 3/4 adverse events were diarrhea (13.8%),neutropenia (8.9%),rash (5.7%) and vomiting (5.7%).CONCLUSION:In patients from Asia and Australia,this study confirm-s the activity and safety of cetuxim-ab plus irinotecan observed in previous studies in Europe and South America.
AIM：To evaluate the efficacy and safety of cetuxim-ab plus irinotecan in irinotecan-refractory metastatic colorectal cancer （mCRC） patients from South-East Asia and Australia. METHODS：In this open-label,phase Ⅱ study,the main eligibility criteria were epidermal growth factor receptor-positive mCRC with progressive disease within 3 mo of an irinotecan-based regimen as the most recent chemotherapy. Patients received cetuximab 400 mg/m2 initially,then 250 mg/m2 every week,with the same regimen of irinotecan on which the patients had progressed （4 pre-defined regim-ens allowed）. The prim-ary objective was evaluation of progression-free survival （PFS） at 12 wk. Secondary objectives included a further investigation of PFS,and an assessment of the overall response rate （ORR）,duration of response,time to treatment failure （TTF）,overall survival and the safety profile. RESULTS：One hundred and twenty nine patients were enrolled from-25 centers in the Asia-Pacific region and of these 123 received cetuximab plus irinotecan. The most common recent irinotecan regimen used was 180 mg/m2 every 2 wk which had been used in 93 patients （75.6%）. The PFS rate at 12 wk was 50% （95% confidence interval （CI,41-59） and m-edian PFS tim-e was 12.1 wk （95% CI：9.7-17.7）. The ORR was 13.8% （95% CI：8.3-21.2） and disease control rate was 49.6% （95% CI：40.5-58.8）. Median duration of response was 31.1 wk （95% CI：18.0-42.6） and median overall survival was 9.5 mo （95% CI,7.5-11.7）. The median TTF was 11.7 wk （95% CI：9.1-17.4）. Treatment was generally well tolerated. The most common grade 3/4 adverse events were diarrhea （13.8%）,neutropenia （8.9%）,rash （5.7%） and vomiting （5.7%）.CONCLUSION：In patients from Asia and Australia,this study confirm-s the activity and safety of cetuxim-ab plus irinotecan observed in previous studies in Europe and South America.
基金
Supported by Merck KGaA, Darmstadt, Germany
