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Curcumin alters expression of glial fibrillary acidic protein and nestin following chronic cerebral ischemia 被引量：1

Curcumin alters expression of glial fibrillary acidic protein and nestin following chronic cerebral ischemia
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摘要 Astrocytes can alter their appearance and become reactive following chronic cerebral ischemia. In the present study, a rat model of chronic cerebral ischemia was treated with 50 and 100 mg/kg curcumin. Results showed that pathological changes of neuronal injury in hippocampal CA1 area of rats induced by chronic cerebral ischemia were attenuated, as well as upregulated expression of glial fibriliary acidic protein and nestin, in a dose-dependent manner. Astrocytes can alter their appearance and become reactive following chronic cerebral ischemia. In the present study, a rat model of chronic cerebral ischemia was treated with 50 and 100 mg/kg curcumin. Results showed that pathological changes of neuronal injury in hippocampal CA1 area of rats induced by chronic cerebral ischemia were attenuated, as well as upregulated expression of glial fibriliary acidic protein and nestin, in a dose-dependent manner.
作者 Peng Zhang
机构地区 Institute of Neuroscience Chongqing Key Laboratory of Neural Science Department of Pathology
出处 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第9期651-655,共5页 中国神经再生研究（英文版）
基金 the National Natural Science Foundation of China, No. 30973154 Chongqing Science and Technology Commission Foundation, No. 2009BB5270 Chongqing Municipal Education Com-mission Foundation, No. KJ090301
关键词 CURCUMIN chronic cerebral ischemia glial fibrillary acidic protein NESTIN nidogen permanent occlusion of bilateral common carotid arteries curcumin chronic cerebral ischemia glial fibrillary acidic protein nestin nidogen permanent occlusion of bilateral common carotid arteries
分类号 Q255 [生物学—细胞生物学] S851.43 [农业科学—预防兽医学]
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Neural Regeneration Research
2011年 第9期

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