摘要
目的 探讨早孕期血清脂联素、瘦素、肿瘤坏死因子(TNF)α、C-反应蛋白(CRP)水平与胰岛素抵抗指数(IR)的关系.方法 选取2007年10月至2008年7月年在北京安贞医院连续产检并分娩342例为研究对象,跟踪随访至晚孕期根据糖耐量试验分为妊娠期糖尿病组、妊娠期糖耐量受损组、正常妊娠组,测定3组孕妇早孕期血清脂联素、瘦素、TNFα及CRP水平,分析以上细胞因子与IR的关系.结果 342例中有13例患妊娠期糖尿病,19例存在妊娠期糖耐量受损.在其余正常孕妇中选择35名作为对照组.3组孕妇早孕期血清脂联素、瘦素及TNFα、CRP水平有统计学意义.脂联素与IR呈负性相关,瘦素、CRP、TNFα、体质量指数(BMI)与IR呈正相关.结论 早孕期脂联素、瘦素、TNFα及CRP与胰岛素抵抗指数存在相关性,其中TNFα的作用最显著,有可能成为早期预测妊娠期糖尿病的指标.
Objective To explore the relationships between serum levels of adiponectin, leptin,TNF-alpha and CRP (c-reactive protein) versus insulin resistance in early pregnancy. Methods A total of 342 pregnant women delivering at our hospital were recruited from October 2007 to July 2008. Their clinical data were collected and analyzed. According to the 50-g 1-hour oral glucose screening test, they were divided into 3 groups:gestational diabetes, gestational impaired glucose tolerance and normal pregnancy. The serum levels of adiponectin, leptin, TNF-alpha and CRP were determined by ELISA (enzyme-linked immunosorbent assay) and multivariate correlation analysis was used to analyze their relationships with the indices of insulin resistance. Results Among them, there were gestational diabetes ( n = 13) and gestational impaired glucose tolerance (n = 19 ). Thirty-five normal pregnant women were selected as the control group. The result of analysis of variance indicted that adiponectin, leptin and TNF-alpha had significant statistical differences among three groups. Through the multivariate correlation analysis, adiponectin had a adverse correlation with the indices of insulin resistance. Leptin, CRP, TNF-alpha and BMI (body mass index) had positive correlations with the indices of insulin resistance. Conclusion Adiponectin, leptin,TNF-alpha and CRP are correlated with the indices of insulin resistance. And TNF-alpha may become an important predictor of gestational diabetes in early pregnancy.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2011年第15期1058-1060,共3页
National Medical Journal of China
基金
2007年首都医学科学发展基金(2007-358)
关键词
妊娠期糖尿病
脂联素
瘦素
TNFΑ
CRP
Gestational diabetes
Adiponetin
Leptin
Tumor necrosis factor-α
CRP