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中电导钙激活的钾通道在大鼠主动脉球囊损伤后的表达及氯沙坦干预研究 被引量：1

mRNA Expression of Intermediate-Condutance Ca^(2+)-Activeted K^+ Channels (IKCa1) in Rat Aortic Intimal Proliferation after Balloon Injury and Losartan Intervention
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摘要 目的研究中电导钙激活的钾通道mRNA在大鼠主动脉球囊损伤后内膜增生中的作用。方法建立大鼠主动脉球囊损伤模型、高脂模型,观察假手术组、单纯球囊损伤后1,4,7,14,28 d组以及高脂、不同剂量氯沙坦下IKCa1 mRNA表达情况。结果球囊损伤后主动脉内膜增生明显,普通饮食28 d组增生达高峰;IKCa1mRNA表达升高,单纯球囊损伤后1 d组达高峰,高脂+球囊损伤时IKCa1 mRNA表达较单纯球囊损伤组1 d组增高,高剂量氯沙坦时IKCa1 mRNA表达下降。结论 IKCa1 mRNA表达增高可能在大鼠主动脉球囊损伤后内膜增生中起重要作用,IKCa1 mRNA表达的增加和下降可能是高脂血症和氯沙坦影响血管内膜增生的机制。 Objective To investigate the mRNA expression of intermediate-condutance Ca2＋-activeted K＋ channels（IKCa1） in rat aortic intimal proliferation after balloon injury.Methods The expression levels of IKCa1 mRNA were detected at different losartan doses and various time points（1,4,7,14,28 days after balloon injury and hyperlipidemia）.Results The maximal intimal proliferation and peak intima-media ratio was found on the 28th day after balloon injury.The peak expression of IKCa1 mRNA was found on the 1st day post-injury.The expression of IKCa1 mRNA upregulation was found in the condition of hyperlipidemia and injury,and downregulation in the condition of high losartan dose.Conclusion The upregulated IKCa1 mRNA expression may play an important role in rat aortic intimal proliferation after balloon injury.Upregulation and downregulation of IKCa1 mRNA expression may be the mechanism by which hyperlipidemia and losartan act on the intimal proliferation.
作者 陈威 颜光烈
机构地区 福建医科大学省立临床学院 福建省立医院心内科
出处 《福建医科大学学报》 2011年第1期15-19,共5页 Journal of Fujian Medical University
关键词 钾通道 钙激活 血管内膜 增生 高脂血症 氯沙坦 疾病模型 动物 Potassium Channels Calcium-Activated Tunica Intima Hyperplasia Hyperlipidemias Losartan Disease Models Animal
分类号 R-332 [医药卫生] R543.02 [医药卫生—心血管疾病]
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参考文献16

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同被引文献14

  • 1王朕华,丰有吉,苏敏,易小芳.钙激活性中电导钾离子通道在子宫内膜癌组织中的表达及其在细胞增殖中的作用[J].中华妇产科杂志,2007,42(2):111-115. 被引量：12
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福建医科大学学报
2011年 第1期

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