Cervitec涂膜的药物释放动力学研究

Study on Drug Release Kinetics of Cervitec Film-Coated Agents

目的研究Cervitec涂膜药效成分的释放动力学行为,为临床评估与合理用药提供参考。方法体外模拟口腔唾液环境,将涂膜Cervitec凝胶剂的前磨牙置于人工唾液中,采用双波长分光光度法测定1-60 d内释放入人造唾液中的药效成分醋酸氯己定和麝香草酚的含量,计算其释放度,绘制释放曲线。结果 Cervitec涂膜对醋酸氯己定与麝香草酚在人工唾液中的释放均主要发生在第1-2 d内,其涂膜后2 d内的释放总量分别为4.4%与18.2%。对醋酸氯己定的释放量第3 d后增幅趋于稳定,而对麝香草酚的释放量在第6 d后增幅趋于稳定;至第30 d时,麝香草酚的总释放度达＂平台期＂;而醋酸氯己定的总释放度在第60 d后到达平台期。结论 Cervitec涂膜一次临床应用后可能在30 d内有效预防和治疗牙本质过敏等症状。

Objective To investigate the drug release kinetics of Cervitec for evaluating its clinical administration and therapeutic effect.Methods The mouth saliva condition was simulated in vitro and bicuspid teeth coated with Cervitec varnish were placed in the artificial saliva.The drug components,chlorhexidine acetate and thymol released from the Cervitec film,were simultaneously measured in the artificial saliva by a double-wavelength spectrophotometry for a period of 1～60 days.The drug release rate was calculated and kinetics curves were drawn.Results The release of chlorhexidine acetate and thymol from the Cervitec film coating mainly occurred in day 1～2,and the total release rate in the first 2 days was 4.4% and 18.2%,respectively.For chlorhexidine acetate,the day release rate stabilized after day 3 and the total release rate reached a ＂platform＂ after 60 days;for thymol,the day release rate stabilized after day 6 and the total release rate reached a platform after 30 days.Conclusion A single application of Cervitec film coating may produce preventive and therapeutic effects on odonthemodia for at least 30 days.