大黄对腹部外科重症手术后抗生素相关性肠炎的预防作用

Preventive Effect of Rhubarb from Antibiotic-associated Colitis in Severe Cases of Abdominal Surgery

目的:观察大黄对外科重症患者术后抗生素相关性肠炎的预防作用。方法:将103例患者随机分为治疗组及对照组。采用粪涂片镜检法判断肠道菌群失调情况,比较两组患者接受抗生素治疗7～10d内抗生素相关性肠炎的发生率及严重程度。结果:103例共发生抗生素相关性肠炎18例,治疗组6例(11.3%),较对照组12例(24.0%)低(P<0.05)。治疗组有1例重度患者及1例Ⅲ度肠道菌群失调,较对照组的7例和8例均明显减少(P<0.05)。结论:大黄可减少外科重症患者术后并发抗生素相关性肠炎,尤其是降低重度患者及Ⅲ度肠道菌群失调的发生率。

Objective To observe the preventive effect of rhubarb from antibiotic-associated colitis （AAC） in severe cases of abdominal surgery.Methods One hundred and three cases were divided into treatment group and control group randomly.The incidence of intestinal flora imbalance was diagnosed by stool smear of Gram stain.The incidence and severity of AAC and the degree of intestinal flora imbalance from 7 to 10 day antibiotic treatment in the two groups were compared.Results The total incidence of AAC was 17.5% in which 11.3% was in the treatment group and 24.0% in control group （P〈0.05）.There were 1 case of severe AAC and 1 case of III degree intestinal flora imbalance in the treatment group （P〈0.05）.Conclusion Rhubarb is beneficial to the prevention of AAC in severe case of abdominal surgery,it can decrease the incidence of AAC and that of III degree intestinal flora imbalance.